Risk of liver damage during the treatment with tumor necrosis factor antagonists
Authors:
O. Šléglová
Authors place of work:
Revmatologický ústav, Praha
Published in the journal:
Čes. Revmatol., 25, 2017, No. 4, p. 184-189.
Category:
Review Article
Summary
Treatment with tumor necrosis factor antagonists can cause drug-induced liver damage. However, after a thorough analysis of detected cases and prospective studies aimed at monitoring liver damage, it can be concluded that the risk of severe hepatic damage is relatively low and treatment can therefore be considered as safe. Most authors emphasize the need for consistent monitoring of patients with early detection of potential hepatotoxicity. A multidisciplinary approach is recommended in further decision making. Some authors consider liver biopsy
a key examination. However, standard recommendations for hepatic damage during treatment with tumor necrosis factor antagonists, including treatment recommendations, are lacking.
Key words:
Treatment with tumor necrosis factor alpha antagonists, liver toxicity, autoimmune rheumatic diseases
Zdroje
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Štítky
Dermatology & STDs Paediatric rheumatology Physiotherapist, university degree Internal medicine Cardiology Orthopaedics RheumatologyČlánok vyšiel v časopise
Czech Rheumatology
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