IL-40 – a new cytokine in the pathogenesis of rheumatic diseases
Authors:
L. Andres Cerezo; A. Navrátilová; L. Šenolt
Authors place of work:
Revmatologický ústav Praha a 1. LF UK, Praha
Published in the journal:
Čes. Revmatol., 30, 2022, No. 2, p. 74-79.
Category:
Review Article
Summary
IL-40 is a recently described cytokine associated with malignancies and autoimmune rheumatic diseases. It is mainly produced by immune cells, in particular by activated B lymphocytes and neutrophils. Local and systemic up-regulation of IL-40 was documented in several rheumatic diseases. Levels of IL-40 are elevated in the serum and in the synovial fluid of RA patients and correlate with neutrophil activation and the levels of autoantibodies. Serum IL-40 decreases following different therapies in RA and participates in the regulation of inflammation and tissue remodeling via activation of neutrophils and synovial fibroblasts. Increased expression of IL-40 was also demonstrated in the serum and the salivary glands of patients with Sjögren’s syndrome. Based on the recent data, IL-40 is a multifunctional cytokine implicated in the pathogenesis of autoimmune inflammatory diseases.
Keywords:
Systemic lupus erythematosus – IL-40, rheumatoid arthritis – Sjögren’s syndrome
Zdroje
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Štítky
Dermatology & STDs Paediatric rheumatology RheumatologyČlánok vyšiel v časopise
Czech Rheumatology
2022 Číslo 2
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