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Modified Intravenous Administration of Immunoglobulins in a Female Patientwith the Diagnosis of Pemphigus Vulgaris


Modifikovaná intravenózní aplikace imunoglobulinůu nemocné s diagnózou pemphigus vulgaris

Autorka popisuje 60letou ženu s diagnózou pemphigus vulgaris. Pacientka onemocněla toutochorobou v 56 letech. Systémová terapie prednizonem a imunosupresivy (Methotrexat, Imuran)přinesla pouze přechodné zlepšení. Po klidovém období vždy následovala exacerbace choroby. Popodání adjuvantní terapie Endobulinem i.v. v celkové dávce 20 g, došlo k výraznému a rychlémuzlepšení kožních a slizničních projevů. Pacientka je v remisi od listopadu 1997, t.č. je léčena Predni-sonem 15 mg p.o. denně a Imuranem 50 mg p.o. denně.

Klíčová slova:
pemphigus vulgaris - intravenózní imunoglobuliny - adjuvantní terapie


Authors: O. Faustmannová
Authors‘ workplace: II. dermatovenerologická klinika, LF MU Brno
Published in: Čes-slov Derm, , 2000, No. 3, p. 114-116
Category:

Overview

The author describes a 60-year-old woman with the diagnosis of pemphigus vulgaris. The patientcontracted the disease at the age of 56 years. Systemic therapy with Prednisone and immunosup-pressive preparations (Methotrexate, Imuran) brought only temporary relief. After remission alwaysa new exacerbation of the disease followed. After administration of adjuvant treatment with concen-trated human polyvalent IgG - Endobulin i.v. in a total dose of 20 g a marked and rapid improvementof the skin and mucosal manifestations occurred. The patient is now in remission since November1997, at present she is treated with Prednisone 15 mg p.o. per day and Imuran 50 mg p.o. per day.

Key words:
pemphigus vulgaris - intravenous immunoglobulins - adjuvant therapy

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Labels
Dermatology & STDs Paediatric dermatology & STDs
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