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Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type: A Report of a Case and Review of the Literature


Authors: Tichý M. J.tichý M. 1,2 2;  A. Hluší 3;  J. Urbánek 1
Authors place of work: Klinika chorob kožních a pohlavních LF UP a FN Olomouc přednostka doc. MUDr. D. Ditrichová, CSc. 1;  Ústav patologické anatomie LF UP a FN Olomouc přednosta doc. MUDr. Martin Tichý, CSc. 2;  Hematoonkologická klinika LF UP a FN Olomouc přednosta prof. MUDr. K. Indrák, DrSc. 3
Published in the journal: Čes-slov Derm, 83, 2008, No. 2, p. 73-76
Category: Case Reports

Summary

Primary cutaneous diffuse large B-cell lymphoma – leg type (PCLBCL) belongs among cutaneous B-cell lymphomas with relatively aggressive clinical behaviour. The authors describe a single case of 68-year-old man with PCLBCL and characterize clinical, histopathological and immunohistochemical features of PCLBCL and give an overview of current literature.

Key words:
WHO-EORTC classification for cutaneous lymphomas – diffuse large B-cell lymphoma, leg type – differential diagnostics


Zdroje

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3. Grange F, Bekkenk MW, Wechsler J, et al. Prognostic factors in primary cutaneous large B-cell lymphomas: a European multicenter study. J Clin Oncol, 2001,19, p. 3602-3610.

4. Grange F, Petrella T, Beylot-Barry M, et al. Bcl-2 protein expression is the strongest independent prognostic factor of survival in primary cutaneous large B-cell lymphomas. Blood, 2004,103, p. 3662-3668.

5. Hallermann C, Kaune KM, Gesk S, et al. Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6 and MALT1 gene loci in primary cutaneous B-cell lymphomas. J Invest Dermatol, 2004, 123, p. 213-219 .

6. Hallermann C, Kaune K, Siebert R, et al. Cytogenetic aberration patterns differ in subtypes of primary cutaneous B-cell lymphomas. J Invest Dermatol, 2004,122, p. 1495-1502.

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10. Jaffe ES, Harris NL, Stein H, Vardiman JW(Eds). World Health Organization Classification of Tumors: Pathology and Genetics of Tumours of Hematopoietic and Lymphoid Tissues. Lyon, France: IARC Press, 2001.

11. Tichý M j, Tichý M. Primární lymfomy kůže – aktuální pohled. Čes-slov Derm, 2000, 75(6), p. 312-318.

12. Tichý M j., Tichý M, Brychtová S. Nové diagnostické, prognostické a terapeutické aspekty primárních kožních lymfomů. Klin Onkol, 2006, 19(5), p. 245-251.

13. Vermeer MH, Geelen FAMJ, van Haselen CW, et al. Primary cutaneous large B-cell lymphomas of the legs: a distinct type of cutaneous B-cell lymphoma with an intermediate prognosis. Arch Dermatol, 1996, 132, p. 1304-1308.

14. Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood, 2005, 105, p. 3768-3785.

15. Willemze R, Kerl H, Sterry W, et al. EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer (EORTC). Blood, 1997, 90, p. 354-371.

Štítky
Dermatology & STDs Paediatric dermatology & STDs
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