Association of HLA-DR and -DQ Alleles with Pemphigus Vulgaris in Slovak Population
Authors:
Z. Párnická 1; N. Rakovan 2; D. Švecová 2; M. Buc 1
Authors place of work:
Imunologický ústav LFUK, Bratislava
prednosta prof. MUDr. Milan Buc, DrSc.
1; Dermatovenerologická klinika LFUK, Bratislava
prednostka prof. MUDr. Mária Šimaljaková, PhD.
2
Published in the journal:
Čes-slov Derm, 85, 2010, No. 3, p. 148-152
Category:
Clinical and laboratory Research
Summary
Pemphigus vulgaris (PV) is an autoimmune disease with genetic predisposition associated mostly with HLA complex alleles. We examined whether this holds true for Slovak population similarly to other Caucasian populations. In 32 patients the frequency of HLA-DRB1 and DQB1 alleles was examined and compared to healthy population. The statistically significant positive association with alleles DRB1*14 (20,31 % vs. 2,69 %, OR = 9,2, Pc< 0,001) and DRB1*04 (39,06 % vs. 11,16 %, OR = 5,1, Pc< 0,001) was found. DQB1*03 and DQB1*05 alleles were more frequent but not on a significant level. DQB1*06 were significantly lower in PV patients in comparison with control group (3,12 % vs. 20,61 %; OR = 0,12, Pc = 0,002). Lower, statistically non-significant frequency was noted for DRB1*11 and DRB1*15 alleles. These results correspond well with the literature and help to overall genetic characteristics of the disease.
Key words:
pemphigus vulgaris – HLA complex and diseases – Slovak population
Zdroje
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Štítky
Dermatology & STDs Paediatric dermatology & STDsČlánok vyšiel v časopise
Czech-Slovak Dermatology
2010 Číslo 3
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