Current Developments and New Treatment Options in the Therapy of Melanoma
Authors:
I. Krajsová
Authors place of work:
Dermatovenerologická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. J. Štork, CSc
Published in the journal:
Čes-slov Derm, 85, 2010, No. 4, p. 189-195
Category:
Reviews (Continuing Medical Education)
Summary
Melanoma incidence is consistently rising as well as the detection of early prognostically favourable tumours. However, the number of advanced tumours with high risk of further progression is not decreasing. Adjuvant therapy with IFN α prolongs disease free survival in some patients but has only limited effect on prolongation of the overall survival. Chemotherapy and chemo-immunotherapy is only partially effective and they usually give only short-term response rates. Research of new treatment options is oriented, among others, also on immunomodulatory therapy that could break the immune tolerance of cancer cells. Blocking of the CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) seems to be one of the promising approaches. As long as the results of ongoing clinical trials are not confirmed, the most effective treatment remains an early surgical removal of the tumour.
Key words:
primary melanoma – adjuvant therapy – metastatic melanoma – immunomodulation – anti CTLA 4 – autoimmunity
Zdroje
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Štítky
Dermatology & STDs Paediatric dermatology & STDsČlánok vyšiel v časopise
Czech-Slovak Dermatology
2010 Číslo 4
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