Therapy of the Recurrent Basal Cell Carcinoma by Vismodegib
Authors:
K. Pizinger; T. Fikrle; B. Divišová; M. Kofroňová
Authors place of work:
Dermatovenerologická klinika FN a LF UK Plzeň
přednosta prof. MUDr. Karel Pizinger, CSc.
Published in the journal:
Čes-slov Derm, 90, 2015, No. 2, p. 56-58
Category:
Pharmacologyand Therapy, Clinical Trials
Summary
Vismodegib is a low-molecular inhibitor of hedhe-hog signaling pathway that regulates cell growth. Its activation in adults leads to formation of some tumours, especially, basal cell carcinoma. Authors describe a case of 75-year old patient with unsuccessfully treated advanced, recurrent and inoperable basal cell carcinoma. The tumour healed after six months treatment with vismodegib.
Key words:
basal cell cacinoma – successful treatment with vismodegib
Zdroje
1. ALI, F. R., LEAR, J. T. Systemic treatments for basal cell carcinoma (BCC): the advent of dermato-oncology in BCC. Br. J. Dermatol., 2013, 169, p. 53–57.
2. ALLY, M. S., YANG, J. Y., JOSEPH, T., THOMPSON, B. et al. The use of vismodegib to shrink keratocystic odontogenic tumors in patients with basal cell nevus syndrome. JAMA, 2014, 150, 5, p. 542–545.
3. CHANG, A. L. S., SOLOMON, A. J., HAINSWORTH, J. D., GOLDBERG, L. et al. Expanded access study of patiens with advanced basal cell carcinoma treated with the hedgehog pathway inhibitor, vismodegib. J. Am. Acad. Dermatol., 2014, 70, p. 60–69.
4. LEAR, J. T. Oral Hedgehog-pathway inhibitors for basal cell carcinoma. N. Engl. J. Med., 2012, 366, p. 2225–2226.
5. REYES-HABITO, C. M., ROH, E. K. Cutaneous reaction to chemotherapeutic drugs and targeted therapies for cancer. J. Am. Acad. Dermatol., 2014, 71, p. 217–227.
6. SEKULIC, A., MIGDEN, M. R., ORO, A. E., DIRIX, L. et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N. Engl. J. Med., 2012, 366, p. 2171–2179.
7. US FOOD and DRUG ADMINISTRATION WEB SITE. Vismodegib. Dostupné na www: http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/
Štítky
Dermatology & STDs Paediatric dermatology & STDsČlánok vyšiel v časopise
Czech-Slovak Dermatology
2015 Číslo 2
Najčítanejšie v tomto čísle
- Cutaneous and Mucosal Candidoses
- Penile Lymphoedema in Association with Inflammatory Bowel Disease
- Small Melanomas
- Therapy of the Recurrent Basal Cell Carcinoma by Vismodegib