Rituximab in the Treatment of Pemphigus Vulgaris – Case Report
Authors:
O. Kodet 1,2,3; L. Lacina 1,2,3; Z. Plzáková 1; I. Krajsová 1; J. Štork 1
Authors place of work:
Dermatovenerologická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. Jiří Štork, CSc.
1; Anatomický ústav 1. LF UK, Praha, přednosta prof. MUDr. Karel Smetana, DrSc.
2; BIOCEV – Biotechnologické a biomedicínské centrum Akademie věd a Univerzity Karlovy ve Vestci u Prahy, ředitel prof. MUDr. Pavel Martásek, DrSc.
3
Published in the journal:
Čes-slov Derm, 95, 2020, No. 3, p. 108-114
Category:
Case interpretation
Summary
The authors describes a case of a 18-year-old patient suffering from pemphigus vulgaris in whom adjuvant therapy with rituximab has been initiated due to the protracted course of treatment, frequent exacerbations of the disease, development of multiple complications during long-term systemic corticosteroid therapy and ineffective prior adjuvant therapy (azathioprine, cyclophosphamide, mycophenolate mofetil). Currently, the described patient has been in complete remission of the disease for 21 months only with supportive osteoporosis therapy. Rituximab is a chimeric (murine/human) monoclonal antibody targeting B cell surface receptor CD20 and has been newly introduced to the first line of systemic therapy of pemphigus and induced good therapeutic response and steroid-sparing effect in clinical trials. The authors present an overview of current knowledge about the treatment of this disease with rituximab.
Keywords:
rituximab – pemphigus vulgaris – desmoglein 1 and 3 – CD19 positive B-lymphocytes
Zdroje
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Štítky
Dermatology & STDs Paediatric dermatology & STDsČlánok vyšiel v časopise
Czech-Slovak Dermatology
2020 Číslo 3
Najčítanejšie v tomto čísle
- Darier Disease: Current View. Part II.
- Rituximab in the Treatment of Pemphigus Vulgaris – Case Report
- The Use of Therapeutic Apheresis in Dermatology
- Pretibial Myxedema. Minireview