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Prevalence and Risk Factors of Allergic Diseases in Preschool Children from Industrial and Rural Region of Slovak Republic


Authors: A. Hlavatá 1;  P. Čižnár 1;  Ľ. Palkovičová 2;  K. Rausová 2;  M. Ursínyová 2;  T. Hlavatý 3 ;  E. Reichrtová 2;  M. Benedeková 1;  O. Červeňová 1
Authors place of work: I. detská klinika LFUK a DFNsP, Bratislava prednostka doc. MUDr. O. Červeňová, CSc. 1;  Vedecko-výskumná základňa Slovenskej zdravotníckej univerzity, Bratislava riaditeľ MUDr. J. Kazár, DrSc. 2;  5. interná klinika LFUK a FNsP, Bratislava prednosta prof. MUDr. J. Payer, CSc. 3
Published in the journal: Čes-slov Pediat 2008; 63 (12): 668-676.
Category: Original Papers

Summary

Introduction:
Various studies revealed different prevalence of allergic diseases in industrial and rural regions. Objective of this study was to measure the prevalence of allergic diseases in a cohort of preschool children from industrial and rural region of Slovak Republic and to investigate the influence of regional factors on the development and manifestation of allergy.

Methods:
The study population consisted of 226 children from two regions of Slovak Republic – industrial Bratislava (n=86) and rural Snina (n=140). Children were followed-up from birth within a large epidemiological study. Children were clinically examined every year and their parents were interviewed with questionnaires focusing on exposure to risk and protective factors of allergy. Children were classified as allergic if they had ever been diagnosed as having asthma or eczema or allergic rhinitis. At the age of five the prevalence of allergic diseases in the cohort was measured and statistical analysis of risk factors between allergic and non-allergic children was performed.

Results:
The prevalence of allergic diseases in 5-years old children was 17.7%. There was statistically significant difference in the overall prevalence of allergic diseases between the region of Bratislava and Snina (24.4% vs. 13.6%; p<0.05). Farm animals were raised significantly more frequent in the families of children from Snina as compared with Bratislava. Allergic children of the whole cohort and in both regions individually had less contact with farm animals as non-allergic. Multivariate logistic analyses identified three independent risk factors of allergic disease: contact with farm animals (OR=0.8; 95% KI= 0.09–0.97), family history of allergy of first degree relatives (OR=2.5; 95% KI=1.25–5.0) and introduction of cow milk before the age of 4 months (p=0.03; OR=1.11; 95% KI=1.0–1.25).

Conclusion:
Contact with farm animals was protective for the development of allergic diseases in children at the age of five years. It could explain different prevalence of allergic diseases between industrial and rural region.

Key words:
allergy, asthma, eczema, rhinitis, risk factors, pets, farm animals, breast feeding, family history, Bratislava, Snina


Zdroje

1. Kučera P. Alergeny z roztočů a jejich klinický význam. Klin. Imunol. Alergol. 1998;8: 34–35.

2. Čižnár P, Reichrtová E, Palkovičová L, et al. Prenatal exposure to organochlorine compounds and allergic eczema in one year old chldren. J. Allergy Clin. Immunol. 2004;113: 65.

3. Hlavatá A, Čižnár P, Benedeková M. Environmentálne rizikové faktory vývoja atopie u detí. Čes.-slov. Pediat. 2007;12: 674–683.

4. Cooke RA, van der Veer A. Human sensitization. J. Immunol. 1916;1: 201–205.

5. Pelosi U, Porcedda G, Tiddia F, et al. The inverse association of salmonellosis in infancy with allergic rhinoconjunctivitis and asthma at school-age: a longitudinal study. Allergy 2005;60: 626–630.

6. Illi S, von Mutius E, Lau S, et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 2001;322: 390–395.

7. Riedler J, Eder W, Oberfeld G, et al. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin. Exp. Allergy 2000;30: 194–200.

8. Naleway AL. Asthma and atopy in rural children: is farming protective? Clin. Med. Res. 2004;2: 5–12.

9. Brussee JE, Smit HA, van Strien RT, et al. Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years. J. Allergy Clin. Immunol. 2005;115: 946–952.

10. Jaakkola JJ, Jaakkola N, Piipari R, et al. Pets, parental atopy, and asthma in adults. J. Allergy Clin. Immunol. 2002;109: 784–788.

11. Tilandyová D, Uhlarová M, Samel L, et al. Incidence of pollinosis in school-age children in urban and rural areas. Čes.-slov. Pediat. 1989;44: 459–462.

12. Majkowska-Wojciechowska B, Pelka J, Korzon L, et al. Prevalence of allergy, patterns of allergic sensitization and allergy risk factors in rural and urban children. Allergy 2007;62: 1044–1050.

13. Pohunek P, Slámová A, Zvárová J, et al. Prevalence průduškového astmatu, ekzému a alergické rýmy u školních dětí v České republice. Čes.-slov. Pediat. 1999;2: 60–68.

14. Butland BK, Strachan DP, Lewis S, et al. Investigation into the increase in hay fever and eczema at age 16 observed between the 1958 and 1970 British birth cohorts. BMJ 1997;315: 717–721.

15. Strachan D, Sibbald B, Weiland S, et al. Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC). Pediatr. Allergy Immunol. 1997;8: 161–176.

16. Kulig M, Bergmann R, Klettke U, et al. Natural course of sensitization to food and inhalant allergens during the first 6 years of life. J. Allergy Clin. Immunol. 1999;103: 1173–1179.

17. Health effects of outdoor air pollution. Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society. Am. J. Respir. Crit. Care Med. 1996;153(1): 3–50.

18. Bergmann RL, Edenharter G, Bergmann KE, et al. Socioeconomic status is a risk factor for allergy in parents but not in their children. Clin. Exp. Allergy 2000;30: 1740–1745.

19. Moffatt MF, Cookson WO. The genetics of asthma. Maternal effects in atopic disease. Clin. Exp. Allergy 1998;28 (Suppl 1): 56–61; discussion 65–66.

20. Lin S, Gomez MI, Hwang SA, et al. Self-reported home environmental risk factors for childhood asthma: a cross-sectional study of children in Buffalo, New York. J. Asthma 2008;45: 325–332.

21. Kuchta M, Spišáková E, Spišák B, et al. Passive smoking as a risk factor for allergic diseases in children. Čes.--slov. Pediat. 1989;44: 714–715.

22. Takenaka H, Zhang K, Diaz-Sanchez D, et al. Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: direct effects on B-cell IgE production. J. Allergy Clin. Immunol. 1995;95: 103–115.

23. von Mutius E. The influence of birth order on the expression of atopy in families: a gene-environment interaction? Clin. Exp. Allergy 1998;28: 1454–1456.

24. Douwes J, Cheng S, Travier N, et al. Farm exposure in utero may protect against asthma, hay fever and eczema. Eur. Respir. J. 2008; in press.

25. Almqvist C, Egmar AC, van Hage-Hamsten M, et al. Heredity, pet ownership, and confounding control in a population-based birth cohort. J. Allergy Clin. Immunol. 2003;111: 800–806.

26. Kull I, Almqvist C, Lilja G, Pershagen G, Wickman M. Breast-feeding reduces the risk of asthma during the first 4 years of life. J. Allergy Clin. Immunol. 2004;114: 755–760.

27. Laubereau B, Brockow I, Zirngibl A, et al. Effect of breast-feeding on the development of atopic dermatitis during the first 3 years of life – results from the GINI-birth cohort study. J. Pediatr. 2004;144: 602–607.

28. Friedman NJ, Zeiger RS. The role of breast-feeding in the development of allergies and asthma. J. Allergy Clin. Immunol. 2005;115: 1238–1248.

29. Muraro A, Dreborg S, Halken S, et al. Dietary prevention of allergic diseases in infants and small children. Part III: Critical review of published peer-reviewed observational and interventional studies and final recommendations. Pediatr. Allergy Immunol. 2004;15: 291–307.

30. Dunlop AL, Reichrtová E, Palkovičová L, et al. Environmental and dietary risk factors for infantile atopic eczema among a Slovak birth cohort. Pediatr. Allergy Immunol. 2006;17: 103–111.

31. Fiocchi A, Assa’ad A, Bahna S. Food allergy and the introduction of solid foods to infants: a consensus document. Adverse Reactions to Foods Committee, American College of Allergy, Asthma and Immunology. Ann. Allergy Asthma Immunol. 2006;97: 10–20; quiz 21, 77.

Štítky
Neonatology Paediatrics General practitioner for children and adolescents
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