Incidence of idiopathic enteric inflammations in children and adolescents in the Plzeň (Pilsen) Region in 2001–2011.
A Prospective study

Česká verzia

Authors: J. Schwarz; J. Sýkora
Authors place of work: Dětská klinika FN a LF UK, Plzeň přednosta prof. MUDr. J. Kobr, Ph. D.
Published in the journal: Čes-slov Pediat 2013; 68 (3): 149-156.
Category: Original Papers

Summary

The objective of the work was to verify the incidence of idiopathic bowel disease (IBD) inflammations in the Plzeň Region (PLK) in children up to 19 years old and to determine, whether there are any geographic or demographic differences in their incidence in a precisely defined area of PLK.

Method:
The data of newly diagnosed patients of the Children Clinic, Pilsen Faculty Hospital, fulfilling the IBD diagnostic criteria were collected prospectively. IBD was diagnosed according to recommendations of professional medical societies.

Results:
128 patients were enrolled into the study, 74 of them with the Crohn’s disease and 52 children with ulcerous colitis (UC), and two patients were found to suffer from inflammatory bowel disease unclassified. The age median at the time of diagnosis in the group of up to 19 years of age proved to be 14.1 years (range 1.4–18.3). In the group of patients up to 15 years these data were 11 .7 (1.4–15). Incidence for 100,000 children up to 19 years of age/year in PLK was 9.24 (IBD), 5.14 (CD) and 4.03 (UC), the data for the group up to 15 years being 7.28 (IBD), 4.37 (CD) and 2.91 (UC).

Conclusion:
Information obtained about 128 children and adolescents suffering from BD in PLK in the period of 2001-2011 demonstrated increasing incidence compared with the period of 1900-2001 and a shift in establishment of diagnosis to the younger age group, which corresponds to the worldwide trends. A higher incidence was demonstrated in town with the population of 5 to 10,000 (p<0.01), communities with population up to 5 thousands had lower IDB incidence than the towns (p<0.01). A higher incidence of CD was found in women in the Tachov district (p<0.01), and in men of the Plzeň – North district (p<0.01), where the incidence of UC was higher (p<0.01). The significantly lower incidence of IBD (p<0.01) and UC (p<0.05) occurred in the Klatovy district.

The results made it clear that life environment plays a role in the development of IBD. Specific risk factors of the environment in the development of IBD should be analyzed in the Tachov district and Plzeň – North district prospectively in relation to the development of IBD.

Key words:
Pilsen region, child age, incidence, idiopathic bowel disease inflammation, Crohn’s disease, ulcerous colitis

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