ACTH dependent Cushing´s syndrome – case report

Česká verzia

Authors: J. Lhotská ¹; J. David ¹; F. Votava ¹; M. Kršek ²
Authors place of work: Klinika dětí a dorostu, Fakultní nemocnice Královské Vinohrady a 3. lékařská fakulta Univerzity Karlovy, Praha ¹; II. interní klinika, Fakultní nemocnice Královské Vinohrady a 3. lékařská fakulta Univerzity Karlovy, Praha ²
Published in the journal: Čes-slov Pediat 2018; 73 (2): 90-94.
Category: Case Report

Věnováno významnému životnímu jubileu prof. MUDr. Lidky Lisé, DrSc.

Summary

In the European population, the prevalence of endogenous Cushing’s syndrome is low, in paediatric population it is unknown. Cushing’s syndrome is a rare disease with high morbidity and mortality. Differential diagnosis of hypercortisolism is complex and can require sophisticated assessment tools.

Our report presents a case of a rare ACTH dependent Cushing’s syndrome, including differential diagnosis and treatment.

Key words:
ACTH dependent Cushing’s syndrome, hypercortisolism

Zdroje

1. Sharm S, Nieman L, Feelders R. Cushing‘s syndrome: epidemiology and developments in disease management. Clin Epidemiol 2015; 7: 281–293.

2. Holst JM, Horváth-Puhó E, Jensen RB, et al. Cushing’s syndrome in children and adolescents: a Danish nationwide population-based cohort study. Eur J Endocrinol 2017; 176 (5): 567–574.

3. Kubáčková K. Vzácná onemocnění v kostce. Praha: Mladá fronta, 2014.

4. Kršek M, Hána V, Vymazal J, Weichet J. Cushingův syndrom. 1. vyd. Praha: Galén, 2006.

5. Lebl J, Al Taji E, Koloušková S, et al. Dětská endokrinologie a diabetologie. Praha: Galén, 2016.

6. Kršek M. Cushingův syndrom. Interní Med 2013; 15: 368–371.

7. Cuevas-Ramos D, Lim DS, Fleseriu M. Update on medical treatment for Cushing‘s disease. Clin Diabetes Endocrinol 2016; 13 (2): 16.

8. Guaraldi F, Storr HL, Ghizzoni L, et al. Paediatric pituitary adenomas: A decade of change. Horm Res Paediatr 2014; 81: 145–155.

9. Storr HL, Savage MO. Management of endocrine disease: Paediatric Cushing‘s disease. Eur J Endocrinol 2015; 173: 35–45.

10. Hochberg Z, et al. Practical Algorithms in Pediatric Endocrinology. Basel; New York: Karger, 1999.

11. Ilias I, Torpy DJ, Pacak K, et al. Cushing’s syndrome due to ectopic corticotropin secretion: Twenty years’ experience at the National Institutes of Health. J Clin Endocrinol Metab 2005, 90 (8): 4955–4962.