Children born after assisted reproduction in the Czech Republic in 2013–2015

Česká verzia

Authors: A. Šípek jr. ^1,2,3; V. Gregor ^1,4; A. Šípek ^1,3,4,5; J. Klaschka ^6,7; M. Malý ^6,8
Authors place of work: Oddělení lékařské genetiky, Thomayerova nemocnice, Praha ¹; Ústav biologie a lékařské genetiky 1. LF UK a VFN, Praha ²; Ústav lékařské genetiky 3. LF UK, Praha ³; Oddělení lékařské genetiky, Sanatorium Pronatal, Praha ⁴; Centrum lékařské genetiky a reprodukční medicíny Gennet, s. r. o., Praha ⁵; Ústav informatiky Akademie věd České republiky, Praha ⁶; Ústav biofyziky a informatiky 1. LF UK, Praha ⁷; Státní zdravotní ústav, Praha ⁸
Published in the journal: Čes-slov Pediat 2020; 75 (1): 11-15.
Category:

Summary

Objective: Retrospective epidemiological analysis of representation of children born after assisted reproduction in the Czech Republic.

Methods: In this work we used data from the National Register of Reproductive Health from the Institute of Health Information and Statistics of the Czech Republic (IHIS CR) for the period 2013–2015. This National Register keeps registers of newborns, women, birth defects and assisted reproduction.

Results: In the period 2013–2015, 314,938 children were born in the Czech Republic after a spontaneous conception and 8,794 children were from pregnancy using assisted reproductive methods. When divided into children with congenital defect and without congenital defect, the differences between groups are very small – children with congenital defect after spontaneous conception 4.22% and after assisted reproduction 4.54%, children without congenital defect in group after spontaneous conception 95.77 % and after assisted reproduction 95.45%. In the distribution according to the frequency of pregnancy we found a higher proportion of children from multiple pregnancies in the group born after assisted reproduction (11.34%) compared to the group after spontaneous conception (2.81%). In the distribution according to frequency we found congenital defect in single dogs in 4.04%, and in children born from multiple pregnancies in 5.82%. Based on the type of concept and the frequency of pregnancy, we found more birth defects in children born from multiple pregnancies after assisted reproduction (8.62%) than in the spontaneous concept group (5.51%).

Conclusions: In the group of children born after assisted reproduction there is no statistically significantly more congenital defects as a whole than in the group born after spontaneous conception. However, in the group of children born after assisted reproduction there are more children born from multiple pregnancies – twins, triplets. Congenital defects occur more frequently in children from multiple pregnancies, but significantly more in children born from multiple pregnancies after assisted reproduction.

Keywords:

Czech Republic – assisted reproduction – congenital defect – Twins

Zdroje

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