Noonan syndrome and other RASopathies: Aetiology, diagnostic procedures and therapy
Authors:
J. Lebl; S. Koloušková; L. Toni; A. Kodýtková; S. A. Amaratunga; L. Plachý; Š. Průhová
Authors place of work:
Pediatrická klinika 2. lékařské fakulty UK a Fakultní nemocnice Motol, Praha
Published in the journal:
Čes-slov Pediat 2020; 75 (4): 219-226.
Category:
Summary
Noonan syndrome and related conditions are classified as RASopathies due to their shared molecular pathogenesis. They represent frequent developmental syndromes with prevalence ranging from 1:1000 to 1:2500 live-born children, and follow an autosomal dominant mode of inheritance, with up to 60% of cases occurring sporadically due to de novo gene mutations. RASopathies are clinically characterized by the typical facial phenotype, delayed growth, and cardiac disease – predominantly pulmonary stenosis (50–60%) and/or hypertrophic cardiomyopathy (20%). Typical clinical presentations include failure to thrive with developmental delay and macrocephaly in infants, and growth delay with typical facial appearance and heart disease in older children. Adults with Noonan syndrome reach a mean height of only 162.5 cm (males) or 152.7 cm (females), due to the multifactorial growth disorder. Growth hormone administration leads to a final height increase from -2.5 SD to -1.4 SD (mean) and thereby extenuates the height handicap. Since 2020, growth hormone has been approved for treatment in Noonan syndrome in the E.U. by national medicine agencies. Individual treatment decisions are the responsibility of paediatric endocrinologists.
Keywords:
RASopathies – Noonan syndrome – hypertrophic cardiomyopathy – Growth hormone – pulmonary stenosis – growth
Zdroje
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Štítky
Neonatology Paediatrics General practitioner for children and adolescentsČlánok vyšiel v časopise
Czech-Slovak Pediatrics
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Najčítanejšie v tomto čísle
- Noonan syndrome and other RASopathies: Aetiology, diagnostic procedures and therapy
- Noonan syndrome from a paediatric cardiologistˇs perspective
- Etiology and diagnostic approach of growth failure in children born small for gestational age (SGA) with persistent short stature in childhood (SGA-SS)
- Prenatal phenotype of RASopathies