#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Lyme borreliosis in children


Authors: Smíšková Dita;  Blechová Zuzana
Authors place of work: Klinika infekčních nemocí 2. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice Bulovka, Praha
Published in the journal: Čes-slov Pediat 2022; 77 (Supplementum 1): 19-23.
Category: Review
doi: https://doi.org/10.55095/CSPediatrie2022/025

Summary

The Czech Republic is an important endemic area of Lyme borreliosis. Borrelia are transmitted by ticks and have an affinity for many organs and tissues (skin, nervous system, joints, myocardium, etc.). This is associated with a variety of clinical manifestations, with erythema migrans, neuroborreliosis and joint involvement being the most common in children. The basis of laboratory diagnosis is the detection of specific IgM and IgG antibodies, confirming contact with the infectious agent, not the activity of infection. Direct methods are of limited use mainly due to low sensitivity (PCR) or lack of clinical data (investigation of specific cellular immune response). A careful evaluation of the clinical picture, supported by laboratory test results, is the basis for diagnosis. In the early stages of the disease, the effect of antibiotic treatment is very good. An insufficient clinical response should lead to an extension of the diagnostic procedure to other, even non-infectious causes of the symptoms.

Keywords:

Lyme borreliosis – erythema migrans – neuroborreliosis


Zdroje

1. http://szu.cz/publikace/data/2021

2. Wilhelmsson P, Fryland L, Lindblom P, et al. A prospective study on the incidence of Borrelia burgdorferi sensu lato infection after a tick bite in Sweden and on the Aland Islands, Finland (2008–2009). Ticks Tick Borne Dis 2016; 7(1): 712–79.

3. Radolf JD, Caimano MJ, Stevenson B, Hu LT . Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes. Nature Rev Microbiol 2012; 10(2): 87–99.

4. Krupka M, Raška M, Beláková J, et al. Biological aspects of Lyme disease spirochetes: unique bacteria of the Borrelia burgdorferi species group. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2007; 151(2): 175–186.

5. Skogman BH, Hellberg S, Ekerfelt C, et al. Adaptive and innate immune responsiveness to Borrelia burgdorferi sensu lato in exposed asymptomatic children and children with previous clinical Lyme borreliosis. Clin Dev Immunol 2012; 2012: 294587.

6. Knudtzen FC, Andersen NS, Jensen TG, Skarphedinsson S. Characteristics and clinical outcome of Lyme neuroborreliosis in a high endemic area, 1995–2014: a retrospective cohort study in Denmark. Clin Infect Dis 2017; 65(9): 1489–1495.

7. Esposito S, Bosis S, Sabatini C, et al. Borrelia burgdorferi infection and Lyme disease in children. Int J Infect Dis 2013; 17(3): e153–158.

8. Liptáková A, David J, Jonáš J, et al. Závažný průběh autoimunitní encefalitidy u sedmnáctiletého chlapce. Ces slov Pediatr 2020; 75(8): 474–478.

9. Rupprecht TA , Manz KM, Fingerle V, et al. Diagnostic value of cerebrospinal fluid CXCL13 for acute Lyme neuroborreliosis. A systematic review and meta-analysis. Clini Microbiol Infect 2018; 24(12): 1234–1240.

10. Pícha D, Moravcová L, Smíšková D. Prospective study on the chemokine CXCL13 in neuroborreliosis and other aseptic neuroinfections. J Neurol Sci 2016; 368: 214–220.

11. Pietikainen A, Oksi J, Hytonen J. Point-of-care testing for CXCL13 in Lyme neuroborreliosis. Diagn Microbiol Infect Dis 2018; 91(3): 226–228.

12. Wagner JN, Weis S, Kubasta C, et al. CXCL13 as a diagnostic marker of neuroborreliosis and other neuroinflammatory disorders in an unselected group of patients. J Neurol 2018; 265(1): 74–81.

13. Cerar T, Ogrinc K, Cimperman J, et al. Validation of cultivation and PCR methods for diagnosis of Lyme neuroborreliosis. J Clin Microbiol 2008; 46(10): 3375–3379.

14. Krbková L, Kybicová K, Pícha D, et al. Doporučený postup diagnostiky a léčby lymeské borreliózy. Klin Mikrobiol Infekc Lek 2018; 24(3): 88–99.

15. Stanek G, Fingerle V, Hunfeld KP, et al. Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clin Microbiol Infect 2011; 17(1): 69–79.

16. Lochhead RB, Strle K, Arvikar SL, et al. Lyme arthritis: linking infection, inflammation and autoimmunity. Nat Rev Rheumatol 2021; 17(8): 449– 461.

17. Steere AC, Klitz W, Drouin EE, et al. Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide. J Exp Med 2006; 203(4): 961–971.

18. Forrester JD, Mead P. Third-degree heart block associated with lyme carditis: review of published cases. Clini Infect Dis 2014; 59(7): 996–1000.

19. Burakgazi AZ, Henderson CS. Unusual presentation of unilateral isolated probable Lyme optic neuritis. Case Rep Neurol Med 2016; 2016: 7471842.

20. Tuuminen T, Hedman K, Söderlund-Venermo M, Seppälä I. Acute Parvovirus B19 infection causes nonspecificity frequently in Borrelia and less often in Salmonella and Campylobacter serology, posing a problem in diagnosis of infectious arthropathy. Clin Vaccine Immunol 2011; 18(1): 167–172.

21. Van Gorkom T, Sankatsing SUC, Voet W, et al. An enzyme-linked immunosorbent spot assay measuring Borrelia burgdorferi B31-specific interferon gamma-secreting T cells cannot discriminate active Lyme neuroborreliosis from past Lyme borreliosis: a prospective study in the Netherlands. J Clin Microbiol 2018; 56(4): e01695–172018.

22. Delong AK, Blossom B, Maloney EL, Phillips SE. Antibiotic retreatment of Lyme disease in patients with persistent symptoms: a biostatistical review of randomized, placebo-controlled, clinical trials. Contemp Clin Trials 2012; 33(6): 1132–1142.

23. Holzbauer SM, Kemperman MM, Lynfield R. Death due to community-associated Clostridium difficile in a woman receiving prolonged antibiotic therapy for suspected lyme disease. Clin Infect Dis 2010; 51(3): 369– 370.

Štítky
Neonatology Paediatrics General practitioner for children and adolescents
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#