Current perspectives on the aetiology of tall stature in children and adolescents (2): Non-syndromic tall stature

Česká verzia

Authors: Adamovičová Kateřina; Plachý Lukáš; Lebl Jan; Koloušková Stanislava; Průhová Štěpánka
Authors place of work: 2. lékařská fakulta Univerzity ; Karlovy a Fakultní nemocnice, v Motole ; Pediatrická klinika
Published in the journal: Čes-slov Pediat 2022; 77 (Supplementum 3): 18-23.
Category: Comprehensive Report
doi: https://doi.org/10.55095/CSPediatrie2022/054

Summary

Non-syndromic tall stature can be caused by growth hormone overproduction, hyperthyroidism, obesity, hypogonadism, precocious puberty or as constitutional growth acceleration. There are conditions caused by a genetic cause as well such as non-sydromic tall stature, typically familial tall stature or, more rarely, pituitary gigantism, which includes X-linked acrogigantism (XLAG). Tall stature can rarely occur in neurofibromatosis type I or in glucocorticoid resistance. After excluding the common endocrinopathies the patients are, in clinical practice, assigned as “familial tall stature” or “constitutional growth acceleration”. Recently, there have been findings showing that non-syndromic tall stature can be caused by a monogenic cause, which can only be found by detailed genetic testing with precise clinical-genetic evaluation.

Keywords:

tall stature – growth hormone overproduction – FIPA – XLAG – familial tall stature

Zdroje

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Štítky

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2022 Číslo Supplementum 3

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