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Anorexia nervosa from an endocrinologist's point of view


Authors: Novotná Dana 1;  Móriová Barbora 2
Authors place of work: Pediatrická klinika, Fakultní nemocnice Brno a Masarykova univerzita 1;  Psychiatrická klinika, Fakultní nemocnice Brno a Masarykova univerzita 2
Published in the journal: Čes-slov Pediat 2023; 78 (S3): 11-16.
Category: Comprehensive Report
doi: https://doi.org/10.55095/CSPediatrie2023/060

Summary

Anorexia nervosa is a complex psychiatric-metabolic-endocrine disease that has the highest mortality rate among psychiatric diseases. Almost all organs and systems are altered by this disease. Changes in the endocrine system mostly represent the body‘s adaptation to starvation, and after regaining the necessary weight and fat mass, they are spontaneously adjusted. However, it does not apply to all changes. There is a disorder of the hypothalamic-pituitary axis with manifestations of hypogonadotropic hypogonadism, hypercortisolemia, resistance to growth hormone, thyroid dysfunction, hyponatremia and hypooxytocinemia. The production of antidiuretic hormone can also be altered, and a bone metabolism disorder can be diagnosed relatively early and often persists even after recovering from anorexia nervosa. Recently, changes in the intestinal microbiome, lipid metabolism, cytokine production disorders with the development of autoimmunity, and immune function disorders have also been described.

Keywords:

anorexia nervosa, osteoporosis, hypothalamic dysfunction, euthyroid sick syndrome, food intake regulation


Zdroje

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Štítky
Neonatology Paediatrics General practitioner for children and adolescents

Článok vyšiel v časopise

Czech-Slovak Pediatrics

Číslo S3

2023 Číslo S3
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