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Meningococcal infections in childhood


Authors: Roháčová Hana
Authors place of work: Klinika infekčních nemocí, Fakultní nemocnice Bulovka, Praha
Published in the journal: Čes-slov Pediat 2024; 79 (Supplementum 1): 9-12.
Category: Comprehensive Report
doi: https://doi.org/10.55095/CSPediatrie2024/027

Summary

Meningococcal infections count among the most dangerous infectious conditions that may affect humans regardless of their age. Anyway, the age groups at highest risk are children up to age 4 years, and adolescents. Adolescents are not only at risk of being infected but also to become source of infection for the contacts when serving as carriers of Neisseria meningitidis infection.

The incidence of meningoccal infections in the Czech Republic is not high. In 2023 there were 17 cases of invasive meningococcal diseases confirmed.(1) The spectrum of clinical expression is broad. The illnesses may be divided into noninvasive and invasive. In invasive, their morality rate reaches 10% and severe sequelae 20%.(2) The only protection that can prevent illness is vaccination. Thera are now vaccines available against serotypes A, C, W, Y, B.

Keywords:

therapy – meningococcal infections – clinical course – contact protection


Zdroje

1.           Informační systém infekčních nemocí. Dostupné na: https://www.uzis.cz

2.           WHO. Factsheet No. 141. 2015. Dostupné na: http://www.who.int/mediacentre/factsheets/fs141/en/

3.           CDC. Pinkbook: Meningococcal Disease. Dostupné na: https://www.cdc.gov/vaccines/pubs/pinkbook/mening.html

4.           Van Deuren M, et al. Clinical Microbiology Reviews. 2000: 144–166.

5.           Sabra A, Benger J. Meningococcal disease in children: a clinical review. Turk J Pediatr 2011; 53: 477–488.

6.           Národní referenční laboratoř pro meningokokové nákazy, Státní zdravotní ústav v Praze. Kumulativní surveillance dat IMO za období 2013–
2022.

7.           Brouwer MC, Read RC, Van de Beek D. Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis. Lancet Infect Dis 2010; 10: 262–274.

8.           Křížová P. Med praxi 2020; 17(5): 317–320.

9.           Sadarangani, et al. Clin Infect Dis 2015; 60: e27–35.

10.        Gammelgaard LK, Colding H, Hartzen SH, et al. Meningococcal disease and future drug targets, CNS Neurol Disord Drug Targets 2011; 10: 140–145.

11.        WHO. Factsheet. Dostupné na: https://www.who.int/news-room/fact-sheets/detail/meningitis

12.        Hamborsky, et al. Epidemiology and prevention of vaccine-preventable diseases. 14th ed. 2015: 331–46.

Štítky
Neonatology Paediatrics General practitioner for children and adolescents
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