Intravesical therapy of urinary bladder tumours

Česká verzia

Authors: Viktor Soukup; Otakar Čapoun; Michael Pešl; Zuzana Feherová; Tomáš Hanuš
Authors place of work: Urologická klinika 1. LF UK a VFN, Praha
Published in the journal: Ces Urol 2014; 18(2): 85-93
Category: Review article

Summary

According to current guidelines, intravesical treatment should be offered to every patient with non-muscle invasive bladder cancer. The type of intravesical therapy should be based on the risk of recurrence and progression. In patients with low risk Ta tumours, a single intravesical instillation, immediately following resection, is recommended. A full course of intravesical chemotherapy or BCG instillation is recommended in all remaining risk groups. In patients with intermediate-risk tumours, one immediate post-resection administration of intravescial chemotherapy should be followed by one year of full course BCG treatment, or additional intravesical chemotherapy for a maximum of one year. In patients with high-risk tumours, full-dose intravesical BCG for 1–3 years should be administered. In tumours with a high risk of progression, immediate radical cystectomy should be considered. In BCG refractory tumours, a radical cystectomy should be performed as well.

Key words:
urinary bladder tumours, adjuvant intravesical therapy, intravesical chemotherapy, BCG, recurrence, progression.

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