Immunotherapy of prostate cancer
Authors:
Jiřina Bartůňková 1; Radek Špíšek 1; Michal Podrazil 1; Ladislav Jarolím 2
Authors place of work:
Ústav imunologie 2. LF UK a FN Motol, Praha
1; Urologická klinika 2. LF UK a FN Motol, Praha
2
Published in the journal:
Ces Urol 2014; 18(4): 273-278
Category:
Review article
Summary
Immunotherapy has become an increasingly appealing therapeutic strategy for cancer patients. Tumorigenesis a very represents a complex, multistage process. Tumour cells are a heterogeneous population which is developing in the context of a microenvironment of non-tumour cells and tisues, thus forming a complex „ecosystem“. In the early stages of tumour development, the immune system is capable of controlling the cell growth. With advanced tumour growth, immune mechanisms become more or less paralysed and frequently even exert a promoting effect on tumour cell proliferation. In order to be successful, anticancer therapy must take into consideration all the comprehensive aspects of interaction of the immune system and tumour cells, including the microenvironment. This communication discussess current options in immunotherapy of prostate cancer with agents that have advanced into phase III clinical trials.
Key words:
immunotherapy, prostate cancer, clinical trials.
Zdroje
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Štítky
Paediatric urologist Nephrology UrologyČlánok vyšiel v časopise
Czech Urology
2014 Číslo 4
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