Rare case of benign prostatic hyperplasia with extensive fibrolipomatous metaplasia of the prostatic stroma
Authors:
Michaela Krajíčková 1; Zuzana Špůrková 1; Michal Kotlář 2
Authors place of work:
Patologicko‑anatomické oddělení Fakultní nemocnice Na Bulovce, Praha
1; Urologické oddělení Fakultní nemocnice Na Bulovce, Praha
2
Published in the journal:
Ces Urol 2021; 25(3): 213-217
Category:
Case reports
Summary
We report a case of a 79-year-old patient with benign prostatic hyperplasia. He was admitted to the department of urology at our hospital to undergo a transurethral resection of the prostate.
Pathological examination confirmed benign prostatic hyperplasia with areas of extensive fibrolipomatous stromal metaplasia. While the presence of adipose tissue in the prostatic stroma is sporadic, fibrolipomatous stromal metaplasia is an extremely rare finding. It has been described in the literature only once. The main diagnostic task in finding adipose tissue in the prostate stroma is to determine whether it is really benign prostatic tissue with lipomatous stromal rearrangement or the spread of tumor cells of well-differentiated acinar prostatic adenocarcinoma into periprostatic adipose tissue.
Keywords:
Prostatic hyperplasia – metaplasia
Zdroje
1. Giroux V, Rustgi AK. Metaplasia: tissue injury adaptation and a precursor to the dysplasia – cancer sequence. Nature Reviews Cancer 2071; 17(10): 594–604.
2. Zámečník J et al. Patologie, učebnice pro lékařské fakulty. Svazek 1, první vydání, LD, s. r. o. – Prager Publishing 2019: 18–19.
3. Rosai J. Rosai and Ackerman’s Surgical Patholog 10th Edition, New York, Mosby 2011: 59.
4. Antúnez P, Herrero M, Santos‑Briz Terrón Á, et al. Benign prostate hyperplasia with fibro‑fatty stromal metaplasia. Actas Urológicas Españolas (English Edition) 2011; 35(1): 63–64.
5. Herschap B, Zakhia D, Nicolas M. Intraprostatic Adipose Tissue. International Journal of Surgical Pathology 2011; 19(2): 190–190.
6. Cohen RJ, Stables S. Intraprostatic fat. Human Pathology 1998; 29(4): 424–425.
7. Billis A. Intraprostatic fat: does it exist? Human Pathology 2004; 35(4): 525.
8. Sung MT, Eble JN, Cheng L. Invasion of fat justifies assignment of stage pT3a in prostatic adenocarcinoma. Pathology 2006; 38(4): 309–311.
9. Nazeer T, Kee KH, Ro JY, et al. Intraprostatic adipose tissue: a study of 427 whole mount radical prostatectomy specimens. Human Pathology 2009; 40(4): 538–541.
10. Epstein JI et al. Biopsy Interpretation of the Prostate, 4th Edition, Philadelphia, Lippincott Williams & Wilkins 2008: 151–153, 240–241.
11. Alderson M, Grivas P, Milowsky MI, Wobker SE. Histologic Variants of Urothelial Carcinoma: Morphology, Molecular Features and Clinical Implications. Bladder Cancer 2020; 6(2): 107–122.
12. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications. 5th Edition, Philadelphia, Elsevier 2019: 139, 165, 588, 590, 625–626.
Štítky
Paediatric urologist Nephrology UrologyČlánok vyšiel v časopise
Czech Urology
2021 Číslo 3
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