Extraskeletal Myxoid Chondrosarcoma with Neuroendocrine Differentiation
Extraskeletálny myxoidný chondrosarkóms neuroendokrinou diferenciáciou
Prezentujeme prípad extraskeletálneho myxoidného chondrosarkómu (EMCH) s neuroendokrin-nou diferenciáciou. Jednalo sa o subkutánny tumor pravej popliteálnej oblasti u 50-ročnéhomuža. Histologicky mal tumor štruktúru EMCH: bol lobulárny, zložený z malých až stredne veľ-kých buniek podobných chondroblastom, s hyperchrómnymi jadrami a len ojedinele zreteľnýmijadierkami. Fokálne bolo vidno pseudorozetovité usporiadanie buniek okolo kapilár. Ojedinelemali bunky vretenovitý tvar. Stróma nodulov bola silne myxoidná, alcián pozitívna a rezistentnána hyaluronidázu. Imunohistochemicky dávali bunky tumoru difúznu pozitivitu NSE, monoklo-nálneho synaptofyzínu, vimentínu. Negatívne boli: aktíny, desmín, S-100 protein, chromogranín A,neurofilamentový protein, myelínový bázický protein, gliálny fibrilárny kyslý protein, pancytoke-ratín, EMA. Pacient je 4 roky po širokej excízii a aktinoterapii bez recidívy. Neuroendokrinnádiferenciácia bola popísaná v EMCH Chhiengom a spol. v roku 1998 (1). Naše pozorovanie potvr-dzuje tieto prekvapujúce nálezy.
Klíčová slova:
extraskeletálny myxoidný chondrosarkóm - neuroendokrinná diferenciácia
Authors:
M. Zámečník 1,2; M. Michal 3; P. Gomolčák 4
Authors place of work:
Katedra patológie SPAM, Bratislava, vedúci katedry doc. MUDr. D. Daniš, CSc. 2 Oddelenie patológie NsP, Trenčín, primár MUDr. M. Gogora, CSc. 3 Registr nádorů měkkých tkání a kůže, Šiklův patologicko-anatomický ústav FN, Plzeň, prednosta prof. MUDr. F. Fa
1
Published in the journal:
Čes.-slov. Patol., , 1999, No. 3, p. 90-93
Category:
Summary
We describe a case of extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation.The tumor occurred in subcutaneous tissue of the right popliteal region in a 50-year-old man. Itmeasured 5 cm in diameter, was well circumscribed, lobular and gelatinous, and lacked anynecrosis or hemorrhage. Histologically, the tumor structure was a typical of extraskeletal myxoidchondrosarcoma. The lesion was lobulated and contained small to medium-sized chondroblast-like cells with ovoid hyperchromatic nuclei and without prominent nucleoli. The cells createdcords and nests and showed focally a perivascular rosette-like arrangement. A few of the tumorcells were spindle shaped. The myxoid matrix was stained with alcian blue and this reaction wasresistant to prior treatment with hyaluronidase. PAS-positive glycogen was found in the cyto-plasm of some tumor cells. Immunohistochemically, the tumor cells were diffusely positive forneuron specific enolase, monoclonal synaptophysin and vimentin. Following antibodies gave ne-gative results: desmin, actins, S-100 protein, pancytokeratin, epithelial membrane antigen, chro-mogranin A, neurofilament protein, myelinic basic protein, glial fibrillary acidic protein. Thepatient is well four years after the wide excision of tumor and radiotherapy. Neuroendocrinedifferentiation in extraskeletal myxoid chondrosarcoma was described at first by Chhieng et al.in 1998 ( 1 ). Our observation confirms this interesting finding.
Key words:
neuroendocrine differentiation - extraskeletal myxoid chondrosarcoma
Štítky
Anatomical pathology Forensic medical examiner ToxicologyČlánok vyšiel v časopise
Czecho-Slovak Pathology
1999 Číslo 3
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