New Aspects in the Field of MALT Lymphomas of the Stomach
Nové pohledy na problematiku MALT lymfomužaludku
Poznatky o MALT lymfomech žaludku z posledních let umožňují lépe pochopit jejich genezi a nabízíi účinné prostředky k moderní diagnostice. Článek v krátkém přehledu shrnuje tyto poznatkys klinickou a morfologickou charakteristikou tak, aby byl zřejmý výstup v praktické diagnostice.Zvláštní důraz je kladen na charakteristickou translokaci t(11;18) se vznikem fúzního proteinuAPI2-MALT1 s antiapoptotickým účinkem.
Klíčová slova:
MALT lymfom – BCL10 – API2 – MALT1 – IgH
Authors:
J. Soukup
; L. Krsková; V. Campr
Authors‘ workplace:
Ústav patologie a molekulární medicíny 2. LF UK a FN Motol, Praha
Published in:
Čes.-slov. Patol., , 2003, No. 3, p. 120-125
Category:
Overview
The knowledge about MALT lymphomas has dramatically changed in the last few years. Thegenesis of MALT lymphomas has become clearer, and new tools in modern diagnostics are available.This article, as a concise review, summarises the latest data and the clinical and morphologicalcharacteristics with the aspect of routine diagnostics. The characteristic translocation t(11;18)and its chimeric transcript API2-MALT1 with antiapoptotic function is emphasised.
Key words:
MALT lymphoma – BCL10 – API2 – MALT1 – IgH
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2003 Issue 3
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