Gynaecological precanceroses from the clinical perspective – today and tomorrow
Authors:
Lukáš Rob 1
; H. Robová 1
; R. Chmel 1
; P. Škapa 2
Authors place of work:
Gynekologicko porodnická klinika UK 2. LF Praha a FN Motol
1; Ústav patologie a molekulární medicíny UK 2. LF Praha a FN Motol
2
Published in the journal:
Čes.-slov. Patol., 48, 2012, No. 1, p. 9-14
Category:
Reviews Article
Summary
During the last twenty-five years an enormous shift in our knowledge of cancerogenesis in all gynaecological precancerous and cancerous diseases can be seen. Early diagnosis of these lesions of the lower genital tract (vulva, vagina and cervix) is enabled mainly due to easy access. The major role in the pathogenesis of most precancerous lesions can be accounted to high risk human papillomavirus. Recently, new information about HPV genotypisation of single precancerous lesions and single histological cancer types were revealed. Thus we can better estimate the effect of vaccines on different age groups of women in relation to different types of cancer. The development and introduction of prophylactic vaccines into clinical practice was one of the major improvements of current medicine. Precancerous and cancer lesions of endometrium make themselves known by early symptoms such as perimenopausal and postmenopausal bleeding. Optimal diagnostic and therapeutic procedures have to be based on close cooperation between the clinician and pathologist.
Keywords:
precancerosis – HPV – genotyping – screening – prophylactic vaccination
Zdroje
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Štítky
Anatomical pathology Forensic medical examiner ToxicologyČlánok vyšiel v časopise
Czecho-Slovak Pathology
2012 Číslo 1
Najčítanejšie v tomto čísle
- Gynaecological precanceroses from the clinical perspective – today and tomorrow
- Review of precancerous vulvar lesions
- What is new in cervical precanceroses cytodiagnostics?
- Precanceroses of the endometrium, fallopian tube and ovary: a review of current conception