Giant cell interstitial pneumonia without exposure to hard metals
Authors:
Barbora Krajsová; Tomáš Tichý
Authors place of work:
Ústav klinické a molekulární patologie LF UP a FN Olomouc
Published in the journal:
Čes.-slov. Patol., 49, 2013, No. 3, p. 141-143
Category:
Original Article
Summary
We describe the case of a 58-year-old woman with giant cell interstitial pneumonia without any history of exposure to hard metals. Giant cell interstitial pneumonia (GIP) is a rare interstitial lung disease characterized by the presence of numerous multinucleated giant cells in the alveolar spaces. Currently GIP is regarded as secondary interstitial pneumonia. While it has become almost synonymous with hard metal lung disease (cobalt pneumonitis), the literature has also included sporadic cases of GIP without exposure to hard metals. This fact undermines the synonymical relationship between GIP and hard metal lung disease. The alteration of lung tissue in GIP is immunologically mediated. In our patient we found a classical histological picture of GIP with lymphoid hyperplasia. At the time of diagnosis she was being treated for Hashimoto´s thyreoiditis. Later, autoimmune hemolytic anemia and bronchial asthma developed. We suggest that our case supports the hypothesis of the autoimmune ethiology of idiopathic GIPs.
Keywords:
giant cell intersticial pneumonia – hard metals – autoimmunity
Zdroje
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Štítky
Anatomical pathology Forensic medical examiner ToxicologyČlánok vyšiel v časopise
Czecho-Slovak Pathology
2013 Číslo 3
Najčítanejšie v tomto čísle
- Polymerase chain reaction: basic principles and applications in molecular pathology
- Sequencing – classical method
- Next-generation sequencing
- Giant cell interstitial pneumonia without exposure to hard metals