Hamartoma of mature cardiac myocytes.
Autopsy case report
Authors:
Šárka Hadravská 1,2; Magdaléna Dubová 1,2; Markéta Miesbauerová 1,2; Petr Mukenšnabl 1; Ondřej Daum 1,2
; Alois Mádle 3; Karel Smetana 4
Authors place of work:
Šiklův ústav patologie FN Plzeň, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
1; Bioptická laboratoř, s. r. o., Plzeň
2; II. interní klinika FN Plzeň, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
3; Interní oddělení FN Plzeň, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
4
Published in the journal:
Čes.-slov. Patol., 53, 2017, No. 4, p. 185-187
Category:
Original Article
Summary
Hamartoma of mature cardiac myocytes (HMCM) is a rare benign pseudoneoplastic myocardial lesion. We describe a case of 39-year-old Bulgarian woman living in the Czech Republic, who died because of rupture of anterior communicating artery aneurysm, and severe bronchopneumonia. An incidental finding at the autopsy was a whitish unencapsulated and not sharply demarcated tumor of the left ventricle and adjacent area of interventricular septum, which protruded above the plane of section. Microscopically the tumor consisted of various different forms of disorganized hypertrophic mature cardiac myocytes without vacuolization of cytoplasm, focally in a „herringbone“ pattern. Dilated venules and thickened intramural coronary arteries, and intervening bands of connective tissue were present between cardiomyocytes in the tumor. Immunohistochemical staining of MIB1 for the detection of proliferative activity was completely negative. No inflammatory infiltration, adipose tissue or calcifications were present in the tumor.
Keywords:
heart – hamartoma – mature cardiac myocytes
Zdroje
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Štítky
Anatomical pathology Forensic medical examiner ToxicologyČlánok vyšiel v časopise
Czecho-Slovak Pathology
2017 Číslo 4
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Hamartoma of mature cardiac myocytes.
Autopsy case report