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Current nomenclature and histopathological criteria for assessment of the noninflammatory degenerative diseases of the aorta


Authors: Ondřej Fabián
Authors place of work: Ústav patologie a molekulární medicíny 2. LF UK a FN Motol, Praha
Published in the journal: Čes.-slov. Patol., 56, 2020, No. 1, p. 26-31
Category: Reviews Article

Summary

A histopathological examination of the surgical specimen of the aorta usually follows a surgical reconstruction of the aortic aneurysm or dissection. Among the adults, the frequent cause of the aneurysm development is a severe atherosclerosis, while in children the aneurysm or dissection usually come as a complication of genetic syndromes. The common microscopical denominator of those diseases is a medial degeneration of variable degree. For a long time, a terminology of microscopical structural alterations used to be subjective and unsettled. In 2016, the first international guidelines for the histopathological assessment of the non-inflammatory degenerative diseases of the aorta were established. They introduced unified nomenclature, defined individual microscopic alterations and implemented a three-tier grading system. This work aims at practical aspects of the microscopical assessment and interpretation of the degenerative processes in the aorta with regards to the aforementioned consensus.

Keywords:

Aorta – histopathology – Marfan syndrome


Zdroje

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Štítky
Anatomical pathology Forensic medical examiner Toxicology
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