Secondary pulmonary hypoplasia associated with calcified Meckel´s diverticulum with osseous metaplasia

Česká verzia

Authors: Silvia Farkašová Iannaccone ¹; Peter Švajdler ²; Marián Švajdler ³; Dorota Sopková ¹; Ažbeta Ginelliová ⁴; Jana Šprláková ⁵; Miroslava Petrášová ⁵; Lucia Fröhlichová ⁶; Daniel Farkaš ⁴
Authors place of work: Ústav súdneho lekárstva UPJŠ LF, Trieda SNP č. 1, Košice ¹; Cytopathos s. r. o., Bratislava ²; Šiklův ústav patologie, Univerzita Karlova Praha, Lékařská fakulta Plzeň, Bioptická laboratoř s. r. o., Plzeň ³; Úrad pre dohľad nad zdravotnou starostlivosťou, SLaPA pracovisko, Ipeľská 1, Košice ⁴; Detská fakultná nemocnica, Trieda SNP č. 1, Košice ⁵; Oddelenie patológie, Univerzitná nemocnica Louisa Pasteura, Košice ⁶
Published in the journal: Čes.-slov. Patol., 57, 2021, No. 1, p. 44-48
Category: Original Article

Summary

In this paper, we report autopsy findings of a 1-day old full-term mature female neonate with pulmonary hypoplasia diagnosed postnatally. Death was attributed to acute respiratory failure due to hyaline membrane disease. We describe pathological features of calcified Meckel’s diverticulum with osseous metaplasia and inflammatory changes in adjacent peritoneum. As far as we know, this case report documents the youngest patient ever diagnosed with calcified Meckel’s diverticulum with osseous metaplasia.

Keywords:

pulmonary hypoplasia – calcified Meckel’s diverticulum – Meckel’s diverticulum with osseous metaplasia

Zdroje

1. Husain AN, Stocker JT. Color Atlas of Pediatric Pathology. New York: Demos Medical Publishing; 2011: 152.

2. Laudy JA, Wladimiroff JW. The fetal lung. 2: Pulmonary hypoplasia. Ultrasound Obstet Gynecol 2000; 16(5): 482-494.

3. Elsayes KM, Menias CO, Harvin HJ, Francis IR. Imaging manifestations of Meckel‘s diverticulum. AJR Am J Roentgenol 2007; 189(1): 81-88.

4. Sagar J, Kumar V, Shah DK. Meckel‘s diverticulum: a systematic review. J R Soc Med 2006; 99(10): 501-505.

5. Thurley PD, Halliday KE, Somers JM, Al-Daraji WI, Ilyas M, Broderick NJ. Radiological features of Meckel‘s diverticulum and its complications. Clin Radiol 2009; 64(2): 109-118.

6. Fink AM, Alexopoulou E, Carty H. Bleeding Meckel’s diverticulum in infancy: unusual scintigraphic and ultrasound appearances. Pediatr Radiol 1995; 25(2): 155–156.

7. Higaki S, Saito Y, Akazawa A, et. al. Bleeding Meckel‘s diverticulum in an adult. Hepatogastroenterology 2001; 48(42): 1628-1630.

8. Ernst LM, Ruchelli E, Carreon CK, Huff DS. Color Atlas of Human Fetal and Neonatal Histology. New York Dordrecht Heidelberg London: Springer; 2011: 84.

9. Kopáčová M, Vykouřil L, Vacek Z, Tyčová V, Bártová J, Rejchrt S, Bureš J. Inverted Meckel´s diverticulum with ectopic pancreatis tissue as source of severe gastrointestinal bleeding. J Gastrointest Surg 2010; 14(3): 578-581.

10. Dearden C, Humphreys WG. Meckel‘s diverticulum: a vesico-diverticular fistula. Ulster Med J 1983; 52(1): 73–74.

11. Kabir SA, Raza SA, Kabir SI. Malignant neoplasms of Meckel‘s diverticulum; an evidence based review. Ann Med Surg 2019; 43: 75-81.

12. Al-Lami A, Alam M, Nagy A, Khan AR. A microscopically calcified Meckel´s diverticulum: a histopathological perspective of a case of both gastric and pancreatic mucosae. BMJ Case Rep 2013: bcr2012008289.

13. Van Landingham SB, Symmonds RE Jr. Calcification of Meckel›s diverticulum. Arch Surg 1982; 117(2): 248.

14. Clemente G, Ionta R, Sarno G, Ricci R, Nuzzo G. Calcified Meckel‘s diverticulum: an unusual incidental finding during laparoscopy. Am J Surg 2007; 193(4): 482-483.

15. Triebwasser JE, Treadwell MC. Prenatal prediction of pulmonary hypoplasia. Semin Fetal Neonatal Med 2017; 22(4): 245-249.

16. Knox WF, Barson AJ. Pulmonary hypoplasia in a regional perinatal unit. Early Hum Dev 1986; 14(1): 33-42.

17. Deutsch GH, Young LR, Deterding RR, et. al. Diffuse lung disease in young children: application of a novel classification scheme. Am J Respir Crit Care Med 2007; 176(11): 1120-1128.

18. Aghabiklooei A, Goodarzi P, Kariminejad MH. Lung hypoplasia and its associated major congenital abnormalities in perinatal death: an autopsy study of 850 cases. Indian J Pediatr 2009; 76(11): 1137-1140.

19. Nakamura Y, Harada K, Yamamoto I, et. al. Human pulmonary hypoplasia. Statistical, morphological, morphometric, and biochemical study. Arch Pathol Lab Med 1992; 116(6): 635-642.

20. Askenazi SS, Perlman M. Pulmonary hypoplasia: lung weight and radial alveolar count as criteria of diagnosis. Arch Dis Child 1979; 54(8): 614-618.

21. Fujioka K, Morioka I, Nishida K, et. al. Pulmonary Hypoplasia Caused by Fetal Ascites in Congenital Cytomegalovirus Infection Despite Fetal Therapy. Front Pediatr 2017; 5: 241.

22. Chan ES. Massive ascites and severe pulmonary hypoplasia in a premature infant with meconium peritonitis and congenital cytomegalovirus infection. Fetal Pediatr Pathol 2019; 39(1): 71-77.

23. Swischuk LE, Richardson CJ, Nichols MM, Ingman MJ. Primary pulmonary hypoplasia in the neonate. J Pediatr 1979; 95(4): 573-577.

24. Kiraly-Borri C, Jevon G, Ji W, et. al. Siblings with lethal primary pulmonary hypoplasia and compound heterozygous variants in the AARS2 gene: further delineation of the phenotypic spectrum. Cold Spring Harb Mol Case Stud 2019; 5(3): a003699.