Non-conventional types of dysplastic changes in gastrointestinal tract mucosa – review of morphological features of individual subtypes

Česká verzia

Authors: Kateřina Kamaradová ^1,2
Authors place of work: Fingerlandův ústav patologie, Fakultní nemocnice Hradec Králové ¹; AeskuLab Patologie k. s., Praha ²
Published in the journal: Čes.-slov. Patol., 58, 2022, No. 1, p. 38-51
Category: Reviews Article

Summary

Evaluation of the dysplastic changes evolving in mucosa of various segments of gastrointestinal tract is a part of routine practice. Morphologically different or non-conventional types of dysplastic changes are described in the mucosa of gastrointestinal tract besides the most common conventional type of dysplasia. Non-conventional dysplasias can arise de-novo or they can be found in association with chronic gastrointestinal conditions, such as Barrett’s esophagus, chronic atrophic gastritis, and inflammatory bowel disease. Non-conventional types of dysplasia include serrated, crypt base of foveolar dysplasia and lesions as pyloric or oxyntic gland adenoma. Non-conventional types of dysplasia arising in inflammatory bowel disease represent specific category with broad morphological spectrum of changes. The aim of this work is to present a comprehensive review of morphological characteristics of individual subtypes of non-conventional dysplastic changes with focus on differences and specificity in particular parts of gastrointestinal tract and provide a functional handout for daily diagnostic practice.

Keywords:

Dysplasia – intraepithelial neoplasia – non-conventional type – foveolar dysplasia – serrated dysplasia – IBD-associated dysplasia

Zdroje

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