Treatment of diabetes by transplantation of pancreatic islets and insulin-producing cells protected from the immune system by encapsulation

Česká verzia

Authors: Igor Lacík
Authors place of work: Ústav polymérov SAV, v. v. i., Bratislava
Published in the journal: Diab Obez 2024; 24(48): 112-119
Category: Reviews

Summary

It is now clear that cell therapy via transplantation of insulin-producing cells, i.e. primary pancreatic islets or reprogrammed stem cells, is an option for the treatment of type 1 diabetes mellitus (T1DM) in patients in whom the desired control of sugar levels cannot be achieved by insulin administration. The complications associated with long-term use of immunosuppressive drugs represent the key limitation of cell therapy. This limitation can be eliminated by encapsulating the cells in a semipermeable polymeric membrane that provides selective permeation of glucose, insulin, nutrients, and metabolites and prevents efficient permeation of the immune system. An intensive research has been ongoing in the world for the last 40 years to provide a clinical solution to glycemic control by cell therapy without the need for immunosuppressive drugs. The aim of this paper is to provide an overview of the current status of T1DM cell therapy with a focus on encapsulation technologies. This topic is being addressed by hundreds of centers around the world working on various aspects related to this therapy. The author of this paper is working in the field of polymeric microcapsules development for immune protection of transplanted pancreatic islets. This paper does not attempt to saturate the reader with references to the existing extensive literature, but to provide a summary with references mainly to recent articles from which the reader will be able to identify the necessary information in his/her area of interest.

Keywords:

Transplantation – cell therapy – pancreatic islets – β-cells derived from stem cell reprogramming – type 1 diabetes mellitus (T1DM) – encapsulation for immune protection of transplanted cells – immunosuppres-sion

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