Coagulase Negative Staphylococci Isolated from Haemocultures
Koaguláza negatívne stafylokoky izolované z hemokultúr
224 kmeňov KNS izolovaných z hemokultúr od hospitalizovaných pacientovi sme bližšie identifikovali do 11 druhou. Z nich najčastejšími druhmi holi S. epidermidis (73,2 %), S. haemolyticus (7,6 %), S. lugdunensis (6,7 %) a S. hominis (3,6 %). U jednotlivých kmeňov sme zistovali faktory virulencie: produkciu slizu a delta toxinu. Na základe týchto vlastností sme kmene zaradili do biotypov. Zo 164 kmeňov S. epidermidis produkovalo sliz 64,6 % a delta toxin 75,0 %. Zo 17 kmeňov S. haemolyticus produkovalo sliz S a delta toxin 10 kmeňov. Z 15 kmeňov S. lugdunensis produkovalo 9 kmeňov súčasne obidva faktory virulencie. Z S kmeňov S. hominis produkovalo sliz 5 a delta toxin 3 kmene. U kmeňov S. capitis, S. sciuri, S. auricularis a S. caprae sme tieto faktory nedokázali. Najčastejšími biotypmi holi: subtyp 3 (43,3 %), la (26,8 %) a lb (10,3 %). Citlivost KNS na 11 antibakteriálnych látky sme zistovali kvantitatívne stanovením MIC (mg/1). Najúčinnejším antibiotikom bol vankomycín (100%) a tetracyklín (76,8%). Na oxacilín a cefalotín bolo citlivých iba 26,3 % kmeňov. Z 224 KNS 157 (70 %) bolo rezistentných na viac ako S antibakteriálnych látky.
Klíčová slova:
koaguláza-negatívne stafylokoky - faktory virulencie - citlivost na antibakteriálne látky.
Authors:
M. Šimkovičová 1; J. Hanzen 2; P. Milošovič 2; M. Lisalová 2
Authors place of work:
i Štátny zdravotný ústav SR, Bratislava 2 HPL spol. s r. o. mikrobiologické laboratórium, Bratislava
Published in the journal:
Epidemiol. Mikrobiol. Imunol. , 2001, č. 3, s. 117-120
Category:
Summary
224 coagulase-negative strains of staphylococci (CNS) isolated from haemocultures of hospitalized patients were classified finto 11 types. The most frequent one was S. epidermis (73.2 %), S. haemolyticus (7.6 %), S. lugdunensis (6.7 %) and S. hominis (3.6 %). In different strains virulence factors were assessed: production of mucus and delta toxin. Based on these properties the strains were classified finto biotypes. Of 164 strains of S. epidermis mucus was produced by 64.6 % and delta toxin by 75.0 %. Of 17 strains of S. haemolyticus mucus was produced by S and delta toxin by 10 strains. Of 15 strains of S. lugdunensis 9 strains produced both virulence factors. Of S strains of S. hominis 5 strains produced mucus and 3 delta toxin. In strains S. capitis, S. sciuri, S. auricularis, S. caprae these factors were not detected. The most frequent biotypes were: subtype 3 (43.3 %), la (26.8 %) and lb (10.3 %). The sensitivity of CNS to 11 antibacterial substances was assessed quantitatively by estimating the MIC (mg/1). The most effective antibiotic was vancomycin (100 %) and tetracycline (76.8 %). Only 26.3 % strains were sensitive to oxacillin and cefalotine. Of 224 CNS (70 %) were resistant to more than S antibacterial substances.
Key words:
coagulase-negative staphylococci - virulence factors - sensitivity to antibacterial substances.
Štítky
Hygiene and epidemiology Medical virology Clinical microbiologyČlánok vyšiel v časopise
Epidemiology, Microbiology, Immunology
2001 Číslo 3
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