Progresivní multifokální leukoencefalopatie – epidemiologie, imunitní odpověď, klinické rozdíly, léčba

Progresivní multifokální leukoencefalopatie (PML) je závažné onemocnění centrální nervové soustavy s velmi vysokou mortalitou. Příčinou onemocnění je JC virus s vysokou séroprevalencí dosahující až 80 %. PML je typické oportunní onemocnění vyskytující se zejména u syndromu získané imunodeficience u pacientů s hlubokým imunodeficitem. Počet případů PML se však v posledních letech zvyšuje také u všeobecné populace jako důsledek vysoce účinných imunosupresivních a imunomodulačních léčebných postupů. V tomto článku autoři uvádějí virologické a epidemiologické souvislosti a charakteristické projevy PML. Jsou diskutovány možné vztahy humorální a buněčné imunity a jsou zmíněny omezené možnosti léčby včetně profylaxe.

Klíčová slova:

buněčná imunita – poměr CD4/CD8 – sclerosis multiplex – progresivní multifokální leukoencefalopatie

Autoři: S. Snopková ¹; P. Štourač ²; L. Fašaneková ¹; M. Mihalčin ¹; K. Havlíčková ¹; R. Svačinka ¹; P. Volfová ³; P. Snopek ⁴; P. Husa ¹
Působiště autorů: Klinika infekčních chorob FN Brno a LF MU, Brno ¹; Neurologická klinika FN Brno a LF MU, Brno ²; Interní hematoonkologická klinika FN Brno a LF MU, Brno ³; Fakulta humanitních studií UTB, Zlín ⁴
Vyšlo v časopise: Epidemiol. Mikrobiol. Imunol. 68, 2019, č. 1, s. 24-31
Kategorie: Review Article

Souhrn

Klíčová slova:

buněčná imunita – poměr CD4/CD8 – sclerosis multiplex – progresivní multifokální leukoencefalopatie

Zdroje

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2019 Číslo 1

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