Případ utopení pod vlivem brotizolamu, flunitrazepamu a etanolu

Je prezentován případ utopení po požití brotizolamu, flunitrazepamu a etanolu. Kvantitativní toxikologická analýza ukázala, že koncentrace v krvi ze stehenní žíly u brotizolamu byla 0,025 μg/ml, 7-aminoflunitrazepamu (metabolit flunitrazepamu) 0,094 μg/ml a etanolu 0,29 mg/ml. Tyto látky byly detekovány v obsahu žaludku.

Lze usuzovat, že v daném případě bylo příčinou smrti utopení, způsobené vlivem kombinovaného užití brotizolamu, flunitrazepamu a etanolu.

Klíčová slova:
brotizolam – flunitrazepam – ethanol – utopení

Autoři: Naoko Tanaka; Hiroshi Kinoshita; Mostofa Jamal; Eriko Ohkubo; Mitsuru Kumihashi; Kiyoshi Ameno
Působiště autorů: Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750-1 Miki, Kagawa, 761-0793, Japan
Vyšlo v časopise: Soud Lék., 56, 2011, No. 1, p. 5-6
Kategorie: Original Article

Souhrn

Klíčová slova:
brotizolam – flunitrazepam – ethanol – utopení

Zdroje

1. Baselt RC. Flunitrazepam. In: Baselt RC. Drug effects on psychomotor performance. Foster City, CA: Biomedical Publications; 2001: 159-162.

2. Baselt RC. Brotizolam. In: Baselt RC, ed. Disposition of toxic drugs and chemicals in man (8th ed). Foster City, CA: Biomedical Publications; 2008: 181-182.

3. Baselt RC. Flunitrazepam. In: Baselt RC, ed. Disposition of toxic drugs and chemicals in man (8th ed). Foster City, CA: Biomedical Publications; 2008: 633-635.

4. Drummer OH, Syrjanen ML, Cordner SM. Deaths involving the benzodiazepine flunitrazepam. Am J Forensic Med Pathol 1993; 14: 238-243.

5. Drummer OH, Odell M. Benzodiazepines and related drugs. In: The forensic pharmacology of drug of abuse. London: Arnold; 2001: 103-175.

6. Jönsson AK, Holmgren P, Druid H, Ahlner J. Cause of death and drug use pattern in deceased drug addicts in Sweden, 2002-2003. Forensic Sci Int 2007; 169: 101-107.

7. Kinoshita H, Nishiguchi M, Kasuda S, Takahashi M, Ouchi H, Minami T, Matsui K, Yamamura T, Motomura H, Ohtsu N, Yoshida S, Adachi N, Ohta T, Komeda M, Ameno K, Hishida S. Forensic toxicological implication of an autopsy case of mixed drug overdose involving clomipramine, chlorpromazine and flunitrazepam. Soud Lek 2008; 53: 28-30.

8. Kudo K, Ishida T, Hikiji W, Hayashida M, Uekusa K, Usumoto Y, Tsuji A, Ikeda N. Construction of calibration-locking databases for rapid and reliable drug screening by gas chromatography-mass spectrometry. Forensic Toxicol 2009; 27: 21-31.

9. Kurisaki E, Hayashida M, Nihira M, Ohno Y, Mashiko H, Okano T, Niwa SI, Hiraiwa K. Diagnostic performance of TriageTM for benzodiazepines: urine analysis of the dose of therapeutic cases. J Anal Toxicol 2005; 29: 539-543.

10. Moriya F. Advantages and limitations of Triage DOA screening in clinical and forensic drug testing. Chudoku Kenkyu 2008; 21: 273-283.

11. Robertson MD, Drummer OH. Postmortem drug metabolism by bacteria. J Forensic Sci 1995; 40: 382-386.

12. Saito T, Takeichi S, Nakajima Y, Yukawa N, Osawa M. A case of homicidal poisoning involving several drugs. J Anal Toxicol 1997; 21: 584-586.

13. Schulz M, Schmoldt A. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie 2003; 58: 447-474.

14. WickstrŅm E, Amrein R, Haefelfinger P, Hartmann D. Pharmacokinetic and clinical observations on prolonged administration of flunitrazepam. Eur J Clin Pharmacol 1980; 17: 189-196.

Štítky

Anatomical pathology Forensic medical examiner Toxicology

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Článok vyšiel v časopise

Forensic Medicine

2011 Číslo 1

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