Auto-immunity and diabetes mellitus
Authors:
Peter Jackuliak; Juraj Payer
Authors place of work:
V. interná klinika LF UK a UNB, Nemocnica Ružinov, Bratislava
Published in the journal:
Forum Diab 2017; 6(1): 27-30
Category:
Summary
Autoimmune mechanism of various diseases is currently a hot topic in medicine. In diabetology is the autoimmune mechanism typically mentioned in the pathophysiology of type 1 diabetes (T1D), particularly among the young. But there is an increasing number of patients with clinical picture of T1D manifesting in adulthood – a condition known as Latent Autoimmune Diabetes in Adults (LADA). Autoimmune mechanisms are in the last time mentioned also in the process of insulin resistance and even gestational diabetes. Therefor the theory of autoimmunity is now in all areas of diabetology, and even starting to be reflected in the last American Diabetes Association (ADA) guidelines 2017 in the reclassification of diabetes.
Key words:
autoimmunity, diabetes mellitus, diagnosis
Received:
20. 1. 2017
Accepted:
20. 3. 2017
Zdroje
1. [American Diabetes Association]. Classification and Diagnosis of Diabetes. Diabetes Care 2016; 39(Suppl 1): S13-S22. Dostupné z DOI: <http://dx.doi.org/10.2337/dc16-S005/. Erratum in Diabetes Care 2016; 39(9): 1653. Dostupné z DOI: 2. Vrlíková D, Mokáň M. Diabetes mellitus 1. typu a autoimunita. Vnitř Lék 2005; 51(11): 1297–1302.
3. Bonifacio E, Ziegler AG. Advances in the prediction and natural history of type 1 diabetes. Endocrinol Metab Clin North Am 2010; 39(3): 513–525.
4. Novák J, Anděl M. Buněčná imunita v patogenezi diabetes mellitus 1. typu. DMEV 2001; 4(3): 184–190.
5. Devendra D, Liu E, Eisenbarth GS. Type 1 diabetes: recent developments. Brit Med J 2004; 328(7442): 750–754.
6. Campbell-Thompson ML, Atkinson MA, Butler AE et al. The diagnosis of insulitis in human type 1 diabetes. Diabetologia 2013; 56(11): 2541–2543. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–013–3043–5>.
7. Willcox A, Richardson SJ, Bone AJ et al. Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 2009; 155(2): 173–181. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1365–2249.2008.03860.x>.
8. In’t Veld P. Insulitis in human type 1 diabetes: the quest for an elusive lesion. Islets 2011; 3(4): 131–138.
9. Atkinson MA, Eisenbarth GS. Type 1A diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001(9277); 358: 221–229.
10. Morahan G. Insights into type 1 diabetes provided by genetic analyses. Curr Opin Endocrinol Diabetes Obes 2012; 19(4): 263–270. Dostupné z DOI: <http://dx.doi.org/10.1097/MED.0b013e328355b7fe>.
11. Noble JA, Valdes AM. Genetics of the HLA Region in the Prediction of Type 1 Diabetes. Curr Diab Rep 2011; 11(6): 533–542. Dostupné z DOI: <http://dx.doi.org/10.1007/s11892–011–0223-x>.
12. Kantárová D, Buc M. Genetic Susceptibility to Type 1 Diabetes Mellitus in Humans. Physiol Res 2007; 56(3): 255–266.
13. Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. 1974; 2(7892): 1279–1283.
14. MacCuish AC, Irvine WJ, Barnes EW et al. Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease. Lancet 1974; 2(7896): 1529–1531.
15. Baekkeskov S, Aanstoot HJ, Christgau S et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347(6289): 151–156. Erratum in Nature 1990; 347(6295): 782.
16. Lan MS, Lu J, Goto Y et al. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 1994; 13(5): 505–514.
17. Kota SK, Meher LK, Jammula S et al. Clinical profile of coexisting conditions in type 1 diabetes mellitus patients. Diabetes Metab Syndr 2012; 6(2): 70–76. Dostupné z DOI: <http://dx.doi.org/10.1016/j.dsx.2012.08.006>.
18. Tuomi T, Santoro N, Caprio S et al. The many faces of diabetes: a disease with increasing heterogeneity. Lancet 2014; 383(9922): 1084–1094. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(13)62219–9>.
19. Laugesen E, Østergaard JA, Leslie RD. Latent autoimmune diabetes of the adult: current knowledge and uncertainty. Diab Med 2015; 32(7): 843–852. Dostupné z DOI: <http://dx.doi.org/10.1111/dme.12700>. Erratum et Corrigendum. Danish Diabetes Academy Workshop and Workshop Speakers. Latent autoimmune diabetes of the adult: current knowledge and uncertainty. [Diabet Med 2015]
20. Hawa MI, Kolb H, Schloot N, et al. Adult-Onset Autoimmune Diabetes in Europe Is Prevalent With a Broad Clinical Phenotype. Diabetes Care 2013; 36(4): 908–913. Dostupné z DOI: <http://dx.doi.org/10.2337/dc12–0931>.
21. Martinka E, Rončáková M, Mišániková M et al. Autoimunitná inzulítída u pacientov s diabetes mellitus 2. typu. Randomizovaný klinický prieskum u hospitalizovaných pacientov. Vnitř Lék 2016; 62(7–8): 521–533.
22. Hawa MI, Buchan AP, Ola T et al. LADA and CARDS: A Prospective Study of Clinical Outcome in Established Adult-Onset Autoimmune Diabetes. Diabetes Care 2014; 37(6): 1643–1649. Dostupné z DOI: <http://dx.doi.org/10.2337/dc13–2383>.
23. Naik RG, Brooks-Worrell BM, Palmer JP. Latent Autoimmune Diabetes in Adults. J Clin Endocrinol Metab 2009; 94(12): 4635–4644. Dostupné z DOI: <http://dx.doi.org/10.1210/jc.2009–1120>.
24. Fourlanos S, Perry C, Stein MS et al. A clinical screening tool identifies autoimmune diabetes in adults. Diabetes Care 2006; 29(5): 970–975.
25. Tsai S, Clemente-Casares X, Revelo XS et al. Are Obesity-Related Insulin Resistance and Type 2 Diabetes Autoimmune Diseases? Diabetes 2015; 64(6): 1886–1897. Dostupné z DOI: <http://dx.doi.org/10.2337/db14–1488>.
Štítky
Diabetology Endocrinology Internal medicineČlánok vyšiel v časopise
Forum Diabetologicum
2017 Číslo 1
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