Benefit of SGLT2 inhibitors in diabetes mellitus type 2

Česká verzia

Authors: Ján Murín ¹; Jozef Bulas ¹; Martin Wavruch ²; František Mikla ¹; Soňa Kiňová ¹
Authors place of work: I. interná klinika LF UK a UNB, Nemocnica Staré Mesto, Bratislava ¹; Ústav klinickej farmakológie LF UK a UNB, Nemocnica Staré Mesto, Bratislava ²
Published in the journal: Forum Diab 2017; 6(3): 165-167
Category: Topic

Summary

Sodium – glucose co-transporter 2 (SGLT2) inhibitors are a new group of antidiabetic drugs, which supports glucosuria. In EMPA-REG OUTCOME clinical study empagliflozin, an SGLT2 inhibitor, presented a great benefit in type 2 diabetic patients: reduction of all-cause and cardiovascular mortalities, neutral effect in the incidence of myocardial infarctions and a non-significant increase of strokes. The effects of treatment were presented rather early in the study, just some few months for mortality reduction from the beginning of the study.

There exists also other SGLT2 inhibitors and these are tested in other studies. A meta-analysis showed a mortality benefit for this group of antidiabetic drugs, showed a reduction of the incidence of myocardial infarctions and a neutral effect for incidence of strokes.

Key words:
cardiovascular events, meta-analysis of SGLT2 inhibitors studies, mortality, SGLT2 inhibitors

Zdroje

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