Uric acid: pathophysiological implications
Authors:
Fedor Šimko 1; Andrej Dukát 2
Authors place of work:
Ústav patologickej fyziológie LF UK v Bratislave
1; V. interná klinika LF UK a UNB, Nemocnica Ružinov, Bratislava
2
Published in the journal:
Forum Diab 2019; 8(1): 11-14
Category:
Review Article
Summary
Pathophysiologic relations of hyperuricaemia are complex and associations are cinfirmed with cardiovascular, renal, methabolic diseases, endothelial dys-function, arterial hypertension, systemic inflammation, proaggregation and oxidative stress. From the first scientific report about hyperuricaemia in 1871 repeatedly causal relationship of increased uric acid level to several organism´s systems is described.
Keywords:
acid uric – hyperuricemia – pathophysiology
Zdroje
- Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007–2008. Arthritis Rheum 2011; 63(10): 3136–3141. Dostupné z DOI: <http://dx.doi.org/10.1002/art.30520>.
- Whelton A. Hyperuricemia and hypertension. A Confluence of Concepts. Editorial Commentary. Hypertension 2012; 60(5): 1112–1113. Dostupné z DOI: <http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.198341>.
- Gavorník P, Dukát A, Gašpar L et al. Klinický význam a liečba hyperurikémie. Slov Klin Pr 2007; 1(1): 18–20.
- Najmik P. Hyperurikémia. Súč Klin Prax 2007; 4(1): 14–18.
- Masuo K, Kawaguchi H, Mikami H at al. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension 2003; 42(4): 474–480. Dostupné z DOI: <http://dx.doi.org/10.1161/01.HYP.0000091371.53502.D3>.
- Lai S, Mariotti A, Coppola B et al. Uricemia and homocysteinemia: nontraditional risk factors in the early stages of chronic kidney disease. Eur Rev Med Pharmacol Sci 2014; 18(7): 1010–1017.
- Johnson RJ, Kang DH, Feig D et al. Is there a pathogenic role of uric acid in hypertension and cardiovascular and renal disease? Hypertension 2003; 41(4): 1183–1190. Dostupné z DOI: <http://dx.doi.org/10.1161/01.HYP.0000069700.62727.C5>.
- Tangri N, Weiner DE. Uric acid, CKD, and cardiovascular disease: confounders, culprits and circles. Am J Kidney Dis 2010; 56(2): 247–250. Dostupné z DOI: <http://dx.doi.org/10.1053/j.ajkd.2010.06.004>.
- Špinar J, Vítovec J, Pařenica J. Hypertenze a hyperurikemie. Vnitř Lék 2005; 51(1): 82–86.
- Kang DH, Nakagawa T, Feng L et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002; 13(12): 2888–2897.
- Loeffler LF, Navas-Acien A, Brady TM et al. Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999–2006. Hypertension 2012; 59(4): 811–817. Dostupné z DOI: <http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.183244>.
- Šimko F, Šimko J, Fábryová M. ACE-Inhibition and Angiotensin II Receptor Blockers in Chronic Heart Failure: Patophysiological Consideration of the Unresolved Battle. Cardiovasc Drugs Ther 2003; 17(3):287–280.
- Khosla UM, Zharikov S, Finch JL et al. Hyperuricemia induces endothe-lial dysfunction. Kidney Int 2005; 67(5): 1739–1742. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1523–1755.2005.00273.x>.
- Price KL, Sautin YY, Long DA et al. Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol 2006; 17(7): 1791–1795. Dostupné z DOI: <http://dx.doi.org/10.1681/ASN.2006030264>.
- Keenan S. Relation of Uric Acid to Serum Levels of High-Sensitivity CRP, Triglycerides, and HDL-C and to Hepatic Steatosis. Am J Cardiol 2012; 110(12): 1787–1792. Dostupné z DOI: <http://dx.doi.org/10.1016/j.amjcard.2012.08.012>.
Štítky
Diabetology Endocrinology Internal medicineČlánok vyšiel v časopise
Forum Diabetologicum
2019 Číslo 1
Najčítanejšie v tomto čísle
- Gout as a new old problem faced by an outpatient care physician
- Treatment of hyperuricemia
- Hyperuricemia and cardiovascular diseases
- Uric acid: pathophysiological implications