Clinical Experience with the Preparation Miacalcic Nasal Spray
Klinické zkušenosti s preparátem Miacalcic nasal spray
U souboru 120 nemocných byl denně podáván tyrokalcitonin (Miacalcic nasal spray, Novartis, CH) v dávce 200 m.j. = 1 vstřik, spolu s 1000 mg vápníku (Maxi-Kalz 500, Asta Medica, A) 2x1 tableta denně do vody. U skupiny 46 nemocných s různými formami osteoporózy stoupla axiální denzita za rok jen o 1,86 %, ale za tuto dobu vznikly pouze 3 nové vertebrální fraktury (6,51 %). U 10 kostních tumorů nebo metastáz ustoupila intenzita bolesti a zlepšení nastalo již kolem 5. dne. U 23 žen po totální strumektomii stoupla axiální denzita za rok léčby o 3,99 % AM (statisticky významně se odlišuje od ostatních osteoporóz). U 18 osob s m. Sudeck byla průměrná doba léčení 33 dnů. U 14 nemocných s akutní pankreatitidou poklesla koncentrace amyláz v séru i v moči do 4. dne, bolest ustala již 2. dne léčby. U 9 osob s m. Paget klesla aktivita sérové ALP a jejího kostního izoenzymu během 3 týdnů.
Klíčová slova:
tyrokalcitonin - nazální sprej - osteoporóza - kostní tumory - strumektomie - m. Sudeck - m. Paget - akutní pankreatitida
Authors:
J. Kocián
Authors place of work:
Osteocentrum Mediscan, Praha
Published in the journal:
Prakt. Lék. 2001; (4): 212-214
Category:
Summary
To a group of 120 patients daily thyrocalcitonin (Miacalcic nasal spray, Novartis, CH) was administered, 200 i.u. = one spray along with 1000 mg Ca (Maxi-Kalz 500, Asta Medica, A) 2x1 tablet per day in water. In a group of 46 patients with different forms of osteoporosis the axial density increased after one year only by 1.86% AM, but during this period only three new vertebral fractures occurred (6.52%). In 10 bone tumours or metastases the pain intensity declined and improvement occurred already round the 5th day. In 23 women after total goitrectomy the axial density increased after one year of treatment by 3.99% AM (differs statistically significantly from other osteoporoses). In 18 subjects with m. Sudeck the mean period of treatment was 33 days. In 14 patients with acute pancreatitis the serum amylase and urinary level declined by the 5th day. Pain ceased already on the second day of treatment. In 9 subjects with m. Paget the activity of serum ALP and its bone isoenzyme declined within three weeks.
Key words:
thyrocalcitonin - nasal spray - osteoporosis - bone tumours - goitrectomy - m. Sudeck - m. Paget - acute pancreatitis.
Štítky
General practitioner for children and adolescents General practitioner for adultsČlánok vyšiel v časopise
General Practitioner
2001 Číslo 4
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