Primary prevention of the late effects of genotoxic and carcinogenic xenobiotics
Authors:
V. Bencko 1; sr. P. Rössner 2
Authors place of work:
1. lékařská fakulta UK a Všeobecná fakultní nemocnice, Praha
; Ústav Hygieny a epidemiologie
Přednosta: prof. MUDr. Vladimír Bencko, DrSc
1; Ústav experimentální medicíny Akademie věd ČR v. v. i., Praha
Ředitelka: prof. MUDr. Eva Syková, DrSc.
2
Published in the journal:
Prakt. Lék. 2009; 89(8): 414-419
Category:
Reviews
Summary
The effectiveness of protection against undesired late affects of exposure to chemical substances can be monitored using the results of testing the genotoxic activity of chemical substances and compounds, further by biological monitoring of exposure which yields evidence on mutual interaction between the human organism and genotoxic substances and their mixtures, and, finally, by monitoring the biological effect following the response of the organism to these xenobiotics. Biomarkers of exposure, effects and susceptibility have been used for screening and repeated follow-up (monitoring) of selected groups of individuals exposed to xenobiotics, serve as a basis to estimate of the magnitude of exposure to chemical substances from any source including activities associated with life style for both the individual and population groups. Thus, using biomarkers, one can not only to assess the magnitude of exposure to genotoxic substances, but subsequently even estimate of the degree of risk for population groups after environmental and occupational exposure to genotoxic xenobiotics. Primary prevention of consequences of exposure to substances with late effects represents in the first place lowering the magnitude of their exposure and reduction of sequels of interaction between the xenobiotics and human organism. Integral component of primary prevention of late effects of genotoxins is chemoprevention involving rational nutrition with sufficient supply of antioxidants, vitamins, minerals and beneficial essential trace elements.
Key words:
primary prevention; biological monitoring; biomarkers; cytogenetic analysis.
Zdroje
1. Bencko, V. Use of human hair as a biomarker in the assessment of exposure to pollutants in occupational and environmental settings. Toxicology 1995, 101, p. 29-39.
2. Bencko, V., Černá, M., Jech, L. et al. Exposure of breast-fed children in the Czech Republic to PCDDs, PCDFs and dioxin-like PCBs. Environ Toxicol Pharmacol 2004, 18, p. 83-90.
3. Bencko, V. Environmental epidemiology, present chances and challenges for futures. Cent. Eur. J. Public Health 2007, suppl. Nov. 15, p. 6-8.
4. Bencko, V., Rameš, J., Fabiánová, E. et al. Ecological and human health risk aspects of burning arsenic-rich coal. Environ. Geochem. Health 2009, 31, p. 239-243.
5. Bencko, V., Rameš, J., Juříčková, L. Expozice polyhalogenovaným uhlovodíkům a incidence vybraných malignit. Hygiena 2009, 54, s. 40-43.
6. Beskid, O., Binková, B., Dušek, Z., et al. Chromosomal aberrations by fluorescence in situ hybridization (FISH)—Biomarker of exposure to carcinogenic PAHs. Mutat. Res. 2007, 620, 1-2, p. 62-70.
7. Binková, B., Lewtas, J., Míšková, I., et al. Biomarkers studies in Northern Bohemia. Environ. Health Perspect. 1996, 104, Suppl. 3, p. 591-597.
8. Bonassi, S., Norppa, H., Ceppi, M. et al. Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries. Carcinogenesis 2008, 29, 6, p. 1178-1183.
9. Černá, M., Rössner, P. Využití krátkodobých metod k monitorování genotoxických účinků faktorů životního a pracovního prostředí. Čs. Hyg. 1988, 33, s. 105-109.
10. Černá, M., Bencko, V. Polyhalogenated hydrocarbons: body burden of the Czech and Slovak populations. I. Polychlorinated biphenyls. Cent. Eur. J. Public. Health 1999, 7, p. 67-71.
11. Černá, M., Pastorková, A. Bacterial urinary mutagenicity test for monitoring of exposure to genotoxic compounds: a review. Cent. Eur. J. Public. Health. 2002, 10, 3, p. 124-129.
12. Dobiáš, L., Hanzl, J., Rössner, P. a kol. Hodnocení klastogenního účinku formaldehydu u dětí v předškolních a školních zařízeních. Čs. Hyg. 1988, 33, s. 596-604.
13. Dostál, M., Kotěšovec, F., Nožička, J. a kol. Studium nemocnosti u dětí – Vliv znečištěného ovzduší. Ochrana ovzduší 2007, 5-6, s.11-18.
14. Hagmar, L., Bonassi, S., Stromberg, U., et al. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res. 1998, 584, p. 117–4121.
15. Hanzl, J., Rössner, P., Klementová, H. Cytogenetická analýza pracovníků profesionálně exponovaných formaldehydu. Čs. Hyg. 1985, 30, s. 403–410.
16. Herceg, Z. Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors. Mutagenesis 2007, 22, p. 91-103.
17. Holcátová, I., Svačina, Š. Dieta v prevenci a léčbě nádorových onemocnění. In: Svačina, Š., a kol. Klinická dietologie. Praha: Grada, 2008, s. 265-277.
18. IPCS, Environmental Health Criteria, 155. Biomarkers and Risk Assessment; Concepts and Principles. Geneva: WHO 1993, p. 82.
19. Liou, S.H., Lung, J.C., Chen, Y.H., et al. Increased chromosome-type chromosome aberration frequencies as biomarkers of cancer risk in a blackfoot endemic area. Cancer Res. 1999, 59, p. 1481-1484.
20. Norppa, H., Bonassi, S., Hansteen, IL., et al. Chromosomal aberrations and SCEs as biomarkers of cancer risk. Mutat Res. 2006, 600, 1-2, p. 37-45.
21. Novotný, L., Holcátová, I., Bencko, V. Výživa, nádorová a kardiovaskulární onemocnění. Prakt. lék. 2009, 89, 5, s. 230-237.
22. Pelclová, D., Rössner, P., Pícková, J., Hykeš, P. Chromozomální aberace u pracovníků tiskárny. Čas. lék. čes. 1990, 129, s. 1002-1003.
23. Petanová, J., Bencko, V., Tuček, M., Novotný, L. Vliv dopravních emisí na imunitu člověka. Prakt. lék., 2008, 88, 5, s. 284-287.
24. Pohlová, H., Šrám, R.J. Cytogenetic analysis of peripheral blood lymphocytes of workers occupationally exposed to styrene, J. Hyg. Epidemiol. Microbiol. Immunol. 1985, 28, p. 155–161.
25. Rössner, Jr, P., Švecová, V., Milcová, A., a kol. Oxidační změny u řidičů autobusů – Důsledky profesionální expozice. Ochrana ovzduší 2007, 5-6, s. 39-44.
26. Rössner, P., Šrám, R.J., Nováková, J., Lambl, V. Cytogenetic analysis in workers ccupationally exposed to vinylchloride. Mutat. Res. 1980, 73, p. 425-427.
27. Rössner, P., Černá, M., Bavorová, H., et al. Monitoring of human exposure to occupational genotoxicants. Centr. Europ. J. Hlth. 1995, 3, p. 219-223.
28. Rössner, P. Cytogenetická analýza lidských periferních lymfocytů v systému biologického monitorování expozice osob genotoxinům. Hygiena 1996, 41, 3, s. 159-166.
29. Rössner, P., Boffeta, P. Ceppi, M. et al. Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer. Environ. Health Perspect. 2005, 113, p. 517-520.
30. Rössner, P. sr., Bencko, V. Pozdní účinky xenobiotik 1. Mechanismus účinku a jejich výskyt v prostředí. Prakt. lék., 2008, 88, 5, s. 262-266.
31. Rubeš, J., Rybář, R., Věžník, Z., a kol. Vliv znečištěného ovzduší na kvalitu lidských spermií v Praze. Ochrana ovzduší 2007, 5-6, s. 35-38.
32. Rychlíková, E., Rychlík, Š., Beneš, I., Šrám, R. Hodnocení znečištění ovzduší prachem v Teplicích, Prachaticích, v Praze-Libuši a v Praze-Smíchově. Ochrana ovzduší 2007, 5-6, s. 29-34.
33. Sorsa, M., Wilbourn, J., Vainio, H. Human cytogenetic damage as a predictor of cancer risk. Mechanism of carcinogenesis in risk identification. IARC Scientific Publ. 1992, 16, p. 543–554.
34. Srb, V., Rössner, P., Zudová, Z., a kol. Účinek formaldehydu a toluenu na vybrané cytogenetické ukazatele u učňovské mládeže. Čs. Hyg. 1990, 35, s. 66-75.
35. Šmerhovský, Z., Landa, K., Rössner, P. et al. Risk of cancer in an occupationally exposed cohort with increased level of chromosomal aberrations. Environ. Health Perspect. 2001, 109, p. 41-45.
36. Šrám, R.J., Kuleshov, N.P. Monitoring of the occupational exposure to mutagens by the cytogenetic analysis of human peripheral lymphocytes in vivo. Arch. Toxicol., 1980, Suppl. 4, p. 11–18.
37. Šrám, R.J., Landa, K., Samková, I. Effect of occupational exposure to epichlorohydrine on the frequency of chromosome aberrations in peripheral lymphocytes. Mutat.Res. 1983, 122, p. 59–64.
38. Šrám, R.J., Binková, B., Rössner, P., et al. Adverse reproductive outcomes from exposure to environmental mutagens. Mutat Res. 1999, 428, p. 203-215.
39. Šrám, R.J., Beskid, O., Binková, B. et al. Cytogenetic analysis using fluorescence in situ hybridization (FISH) to evaluate occupational exposure to carcinogens. Toxicol Lett. 2004, 149, 1-3, p. 335-44.
40. Šrám, R.J., Rössner, P., Šmerhovský, Z. Cytogenetic analysis and occupational health in the Czech Republic. Mutat Res., 2004, 566, p. 21-48.
41. Šrám, R.J., Binková, B., Dejmek, J., Bobak, M. Ambient Air Pollution and Pregnancy Outcomes: A Review of the Literature. Environ Health Perspect., 2005, 113, 4, p. 375–382.
42. Tuček, M., Bencko, V., Volný, J. a kol. Příspěvek ke zdravotním aspektům expozice výfukovým plynům. Prakt. lék., 2008, 88, 5, s. 300-304.
Štítky
General practitioner for children and adolescents General practitioner for adultsČlánok vyšiel v časopise
General Practitioner
2009 Číslo 8
- Memantine Eases Daily Life for Patients and Caregivers
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
- Metamizole vs. Tramadol in Postoperative Analgesia
- Advances in the Treatment of Myasthenia Gravis on the Horizon
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
Najčítanejšie v tomto čísle
- The calcium score: helper or a bad counsellor in diagnostics of chest pain suspected of coronary origin
- Prostate cancer in the age of the da Vinci robotic radical prostatectomy
- Prevention of venous thrombosis (phlebothromboprophylaxis) in clinical practice
- Incidence of pulmonary embolism in females aged 15–25 years in relation to oral contraception use (Results of a five-year study)