Gastroduodenal complications associated with non-steroidal anti-inflammatory drugs in Slovak Republic: results of one-year prospective study

Česká verzia

Authors: I. Rybár ¹; M. Hlista ²; P. Masaryk ³; J. Rovenský ^1,3; R. Hyrdel ⁴; M. Kriška ⁵
Authors place of work: Katedra reumatológie Fakulty zdravotníctva a špecializačných štúdií Slovenskej zdravotníckej univerzity, Bratislava, Slovenská republika, vedúci prof. MUDr. Jozef Rovenský, DrSc., FRCP ¹; Interné oddelenie NsP, Trenčín, Slovenská republika, prednosta prim. MUDr. Oto Herman ²; Národný ústav reumatických chorôb, Piešťany, riaditeľ prof. MUDr. Jozef Rovenský, DrSc., FRCP ³; II. interná klinika Jeseniovej lekárskej fakulty UK a Centrum pre liečbu rezistentných peptických vredov, Martin, Slovenská republika, prednosta prof. MUDr. Rudolf Hyrdel, CSc. ⁴; Farmakologický ústav Lekárskej fakulty UK, Bratislava, Slovenská republika, vedúci prof. MUDr. Milan Kriška, DrSc. ⁵
Published in the journal: Vnitř Lék 2006; 52(7-8): 673-676
Category: 130th Internal Medicine Day - Rheumatology in clinical practice

Summary

The aim of the one-year prospective study was to estimate the prevalence of non-steroidal anti-inflammatory drugs using in patients with symptomatic gastroduodenal ulcers, the upper gastrointestinal bleeding and perforation (PUB - perforation, ulcer, bleeding). Among of 326 patients with PUB, prevalence of non-steroidal anti-inflammatory drugs using was 60 %. In the group of 194 patients with non-steroidal antiinflammatory drugs induced PUB, 49 % patients took aspirin, 38 % non-aspirin non-steroidal anti-inflammatory drugs and 13 % their combination. Low dosing aspirin (dialy dosis ≤ 200 mg) was associated with PUB in 21 % of patients. Age higher than 60 years and women had statisticaly signiticant higher prevalence of non-steroidal anti-inflammatory drugs induced PUB.

Key words:
non-steroidal anti-inflammatory drugs - peptic ulcer - gastrointestinal bleeding - gastropathy - rheumatic diseases - epidemiology

Zdroje

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