Variability of plasmatic levels of big endothelin and NT-proBNP in patients with heart failure in a chronic haemodialysis programme

Česká verzia

Authors: O. Ludka ¹; J. Špinar ¹; L. Vítovcová ²; D. Sobotová ²; L. Špinarová ³; Z. Pozdíšek ¹; V. Musil ¹; J. Vítovec ³; J. Tomandl ⁴
Authors place of work: Interní kardiologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jindřich Špinar, CSc., FESC ¹; II. interní klinika Lékařské fakulty MU a FN u sv. Anny v Brně, přednosta doc. MUDr. Miroslav Souček, CSc. ²; I. interní kardioangiologická klinika Lékařské fakulty MU a FN u sv. Anny Brno, přednosta prof. MUDr. Jiří Vítovec, CSc., FESC ³; Biochemický ústav Lékařské fakulty MU Brno, přednostka prof. RNDr. Eva Táborská, CSc. ⁴
Published in the journal: Vnitř Lék 2007; 53(11): 1177-1181
Category: Original Contributions

Summary

Inter-dialysis variability in levels of big endothelin and NT-proBNP in plasma were studied in 22 patients with established systolic and/or diastolic dysfunction of the left cardiac ventricle assigned to a chronic haemodialysis programme. The plasmatic level of NT-proBNP in all patients was practically unchanged. There was a falling trended between haemodialysis treatments but this was not statistically significant and in absolute values clinically insignificant. Fluctuations were found between individuals but on average all values were stable and high in the pathological range. No significant changes in the plasmatic level of big endothelin were found either. The average levels were again stable and insignificant and the indicated trend did not achieve clinical or statistical significance. The values were once again high in the pathological range. Plasmatic levels of NT-proBNP and big endothelin do not vary according to the phase of the dialysis cycle and mainly reflect the long-term condition of endothelium failure and long-term stress in the left ventricle. Concentrations are not affected by changes in volume or uraemia between dialysis treatments and the suggested trend towards a fall in NT-proBNP and a rise in big endothelin does not have a clear explanation. In any case, this trend remained within the pathological range and is probably not clinically significant.

Key words:
chronic heart failure - haemodialysis - variability - neurohumoral activation

Zdroje

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