Metabolic importance of muscles and the role of sports in diabetic patients

Česká verzia

Authors: Š. Svačina
Authors place of work: III. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
Published in the journal: Vnitř Lék 2007; 53(5): 545-547
Category:

Summary

Muscle is a very important tissue in pathogenesis of diabetes and its complications. In future muscle will become a target of novel farmacotherapy of diabetes. Sport in diabetes has important cardiovascular effects and limited metabolic effects. Physical activity in diabetes can induce hypo- and hyperglyceaemia. Dosing scheme for insulin and diet was published for sporting in diabetes. Most important is individual selfmonitoring and adjustment of therapy during sporting activities.

Key words:
insulin therapy during sporting – diet therapy during sporting – effect of sport in diabetes – future of diabetes pharmacotherapy – future drugs influencing muscle in diabetes

Zdroje

1. Bluher M, Bullen JW jr, Lee JH et al. Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training. J Clin Endocrinol Metab 2006; 91: 2310-2316.

2. Haluzík M. Svačina Š. Metabolický syndrom a jaderné receptory PPAR. Praha: Grada 2006.

3. Hojlund K, Frystyk J, Levin K et al. Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes. Diabetologia 2006; 49: 1283-1291.

4. Kim JK, Michael MD, Previs SF et al. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. Clin Invest 2000; 105: 1791-1797.

5. Maugham RJ, Burke LM. Výživa ve sportu. Praha: Galén 2002.

6. Nagi D. Exercise and sport in diabetes. Chichester: Wiley 2005.

7. Oh YS, Cho KA, Ryu SJ et al. Regulation of insulin response in skeletal muscle cell by caveolin status. J Cell Biochem 2006; 99: 747-758.

8. Svačina Š. Prevence diabetu. Praha: Galén 2003.

9. Svačina Š et al. Metabolický syndrom. Praha: Triton 2006.