Pathogenesis of insulin resistance in different endocrinopathies

Česká verzia

Authors: V. Ďurovcová; M. Kršek; M. Haluzík
Authors place of work: III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
Published in the journal: Vnitř Lék 2008; 54(4): 368-376
Category: Review

Summary

Visceral obesity, insulin resistance and increased cardiovascular morbidity and mortality are strongly related. Development of visceral obesity and regulation of body fat distribution in general are influenced by many factors. This article is a summary of current knowledge about pathogenesis of insulin resistance in different endocrinopathies, particularly in the Cushingʼs syndrome and acromegaly, as they are both connected with the pathological conditions mentioned above.

Key words:
insulin signaling pathway – visceral obesity – cortisol – growth hormone

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