Langerhans cell histiocytosis (LCH) in orofacial region

Česká verzia

Authors: A. Fassmann ¹; L. Izakovičová Hollá ^{1, 2}; P. Augustín ¹; J. Vokurka ¹; J. Vaněk ¹
Authors place of work: Stomatologická klinika Lékařské fakulty MU a FN u sv. Anny Brno, přednosta prof. MUDr. Jiří Vaněk, CSc. ¹; Ústav patologické fyziologie Lékařské fakulty MU Brno, přednostka prof. MUDr. Anna Vašků, CSc. ²
Published in the journal: Vnitř Lék 2010; 56(Supplementum 2): 85-90
Category: Langerhans cell histiocytosis and some other Hematology rare diseases

Summary

Langerhans cell histiocytosis (LCH) is a rare disease of unknown origin. It is characterized by intense and abnormal proliferation of bone marrow-derived histiocytes (Langerhans cells). This disease has a broad spectrum of forms and severity of clinical manifestations, it invades bones, skin, mucosa as well as the inner organs. This case report describes a 33-year monitoring of a patient with a chronic diffuse form of LCH, so called Hand-Schüller-Christian disease. Apart from skin manifestations, this patient also had infiltrates of the oral mucosa, and osteolytic lesions of the alveolar bone of both upper and lower jaws. These findings helped dermatologists confirm the diagnosis of LCH. The dentist plays an important role in multidisciplinary treatment of patients with LCH as periodic checkups with emphasis on possible oral manifestations can reveal the first signs of LCH.

Key words:
Langerhans cell histiocytosis – histiocytosis X – oral manifestations – infiltrate – bone lesion

Zdroje

1. Pacino GA, Serrat A, Redondo LM et al. Langerhans cell histiocytosis: clinical diagnostic features and current concepts. Med Oral 1999; 4: 607–618.

2. Dagenais M, Pharoah MJ, Sikorski PA. The radiographic characteristics of histiocytosis X. A study of 29 cases that involve the jaws. Oral Surg Oral Med Oral Pathol 1992; 74: 230–236.

3. Shirley JC, Thornton JB. Oral manifestations of Langerhans’ cell histiocytosis: review and report of case. ASDC J Dent Child 2000; 67: 293–296.

4. Blevins C, Dahlin DC, Lovestedt SA et al. Oral and dental manifestations of histiocytosis X. Oral Surg Oral Med Oral Pathol 1959; 12: 473–483.

5. Bartnick A, Friedrich RE, Roeser K et al. Oral Langerhans cell histiocytosis. J Craniomaxillofac Surg 2002; 30: 91–96.

6. Madrigal-Martínez-Pereda C, Guerrero-Rodríguez V, Guisado-Moya B et al. Langerhans cell histiocytosis: literature review and descriptive analysis of oral manifestations. Med Oral Patol Oral Cir Bucal 2009; 14: E222–E228.

7. Hernández-Juyol M, Boj-Quesada JR, Gallego Melcon S. Oral manifestations of Langerhans cell histiocytosis. Case study of a two-year-old boy. Med Oral 2003; 8: 19–25.

8. Mínguez I, Mínguez JM, Bonet J et al. Oral manifestations of chronic disseminated histiocytosis. A report of 10 cases. Med Oral 2004; 9: 149–154.

9. Baumgartner I, von Hochstetter A, Baumert B et al. Langerhans’ cell histiocytosis in adults. Med Pediatric Oncol 1997; 28: 9–14.

10. Nicholson SH, Egeler RM, Nesbit ME. The epidemiology of Langerhans cell histiocytosis. Hematol Oncol Clin North Am 1998; 12: 379–384.

11. Duncan WK, Post AC, McCoy BP. Eosinophilic granuloma. Oral Surg Oral Med Oral Pathol 1988; 65: 736–741.

12. Schepman KP, Radden BG, Van der Waal I. Langerhans’ cell histiocytosis of the jaw bones. Report of 11 cases. Aust Dent J 1998; 43: 238–241.

13. Klein F, Krigar D, Petzoldt D et al. Periodontal manifestation of Langerhans’ cell histiocytosis in a young man: case report with a 24-month follow-up. Quintessence Int 2006; 37: 175–182.

14. Silvestros SS, Mamalis AA, Sklavounou AD et al. Eosinophilic granuloma masquerading as aggressive periodontitis. J Periodontol 2006; 77: 917–921.

15. Howarth DM, Gilchrist GS, Mullan BP et al. Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome. Cancer 1999; 85: 2278–2290.

16. Adam Z, Pour L, Krejčí M et al. Histiocytóza z Langerhansových buněk u osob dospělého věku – nemoc s mnoha tvářemi. Zkušenosti jednoho pracoviště a přehled projevů nemoci. Vnitř Lék 2008; 54: 1063–1080.