Is there a relationship between inflammatory markers, oxidative stress and postoperative atrial fibrillation?

Česká verzia

Authors: F. Sabol ¹; M. Jakubová ²; P. Mitro ³; A. Bomba ⁴; A. Chmelárová ⁴; D. Petrášová ⁴; B. Stančák ³; V. Nagy ⁵; P. Török ²; A. Šebová ⁶
Authors place of work: Klinika srdcovej chirurgie VÚSCH, a. s., Košice, Slovenská republika, prednosta MUDr. František Sabol, PhD. ¹; Klinika anestéziológie a intenzívnej medicíny VÚSCH, a. s., Košice, Slovenská republika, prednosta doc. MUDr. Pavol Török, CSc. ²; Klinika kardiológie VÚSCH, a. s., Košice, Slovenská republika, prednosta doc. MUDr. Branislav Stančák, CSc. ³; Ústav experimentálnej medicíny Lekárskej fakulty UPJŠ Košice, Slovenská republika, prednosta MVDr. Alojz Bomba, DrSc. ⁴; Urologická klinika Lekárskej fakulty UPJŠ a UN L. Pasteura Košice, Slovenská republika, prednosta prof. MUDr. Ladislav Valanský, PhD. ⁵; Klinika rádiodiagnostiky a nukleárnej medicíny UPJŠ a UN L. Pasteura Košice, Slovenská republika, prednosta doc. MUDr. Tatiana Jurgová, CSc. ⁶
Published in the journal: Vnitř Lék 2012; 58(10): 730-734
Category: Original Contributions

Summary

Introduction:
Atrial fibrillation (AF) is one of the most common complications following heart surgery. The aim of this work was to verify the relationship between inflammatory markers, oxidative stress and postoperative arrhythmia.

Methods:
45 patients with ischemic heart disease (12 women and 33 men, mean age 62.3 ± 9.4 years) underwent surgical myocardial revascularization. The extracorporeal circulation (ECC) was used in 30 patients, without ECC was 15 patients. During the first 3 postoperative days was determining the incidence and duration of the AF, laboratory markers of inflammation (CRP, leukocytes, TNFα), malondialdehyde (MDA).

Results:
Demographic data and associated disease were in this patients similar. The incidence of AF we documented in 30 patients (66.7%). In patients with postoperative AF were significantly higher levels of inflammatory markers (leukocytes 13.6 ± 3.6 vs 11.3 ± 3.6; 14.7 ± 3.9 vs 12.5 ± 2.9; 13.7 ± 4.1 vs 11.4 ± 13.7; p ≤ 0.05; CRP 138.1 ± 41.1 vs 69.9 ± 25.8; p ≤ 0.001; TNFα 11.3 ± 14.3 vs 8.7 ± 3.6; 12.1 ± 14.5 vs 8.7 ± 3.1; p ≤ 0.05) compared with patients who were free from AF. Values of MDA were not significantly different.

Conclusion:
Patients with postoperative atrial fibrillation were higher levels of inflammatory markers compared with patients with sinus rhythm but no significant differences in the levels of oxidative stress.

Key words:
atrial fibrillation – heart surgery – inflammatory markers – oxidative stress – postoperative arrhythmia

Zdroje

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