Primary cilia of cells of cardiovascular apparatus

Česká verzia

Authors: J. Dvořák ¹ ; V. Sitorová ²; D. H. Nikolov ²; J. Mokrý ³; I. Richter ^4,5; S. Filip ¹; A. Ryška ²; J. Petera ¹
Authors place of work: Klinika onkologie a radioterapie Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Jiří Petera, Ph. D. ¹; Fingerlandův ústav patologie Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Aleš Ryška, Ph. D. ²; Ústav histologie a embryologie Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Jaroslav Mokrý, Ph. D. ³; Oddělení klinické onkologie Krajské nemocnice Liberec, a. s., Liberec, přednosta prim. MUDr. Jiří Bartoš, MBA ⁴; Lékařská fakulta UK a FN Hradec Králové, děkan prof. MUDr. RNDr. Miroslav Červinka, CSc. ⁵
Published in the journal: Vnitř Lék 2012; 58(12): 938-942
Category: Review

Summary

The primary cilium is a mechanosensory, solitary, non-motile microtubule-based structure that in the quiescent phase of the cell cycle projects from the surface of the majority of human cells, including embryonal, stem and mesenchymal cells, fibroblasts, myoblasts, cardiomyocytes, vascular smooth muscle and endothelial cells. Primary cilia are in increased frequency also present on the surface of endothelial cells in atherosclerotic predilection sites, lipoid streaks and dots and atheromatous plaques. The primary cilium is formed from the mother centriole. Primary cilia are currently studied in mechanobiology of cardiovascular apparatus and their role in cell migration, cell cycle control and atherogenesis. The aim of this paper is to provide a review of the current knowledge on the primary cilia of cells of cardiovascular apparatus.

Key words:
primary cilia – cardiomyocytes – endothelial cells – vascular smooth muscle cells – atherosclerosis

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