Vitamin D – remarks of known and overwiev of new facts

Česká verzia

Authors: H. Matějovská Kubešová ¹; J. Tůmová ²; V. Polcarová ¹; H. Meluzínová ¹
Authors place of work: Klinika interní, geriatrie a praktického lékařství Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednostka prof. MUDr. Hana Matějovská Kubešová, CSc. ¹; Oddělení klinické biochemie FN Brno, pracoviště Bohunice, přednosta doc. MUDr. Milan Dastych, CSc., MBA ²
Published in the journal: Vnitř Lék 2012; 58(3): 196-201
Category: Reviews

Summary

Vitamin D as one of liposolubile vitamins was related to children age and skeleton at the clinical practice until now. There is lot of new information considering rather more complicated connection of vitamin D into many functions of human body during last years. On the other hand we are able to measure the serum level of vitamin D, so we recognized the possibility of long term significantly low levels of vitamin D in tenths percent of population. This review shows actual information about relationsship between vitamin D and organ systems and their disturbances. Long term low level of vitamin D potentiates cognitive deterioration in elderly, influences the mood up to depression appearance. The influence of vitamin D on immunity system and cancerogenesis appears to be of high importance too. From the senior’s independence point of view the relationship between vitamin D and sarcopenia is very important especially in connection with osteoporosis prevention – the way how to reduce the danger of falls and osteoporotic fractures. Autoimmune diseases and diabetes mellitus are mentioned at the end of the review.

Key words:
vitamin D – bone – muscle – sarcopenia – cognitive functions – depression – cancer – autoimmunity – diabetes mellitus

Zdroje

1. Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academy Press, 2010.

2. Vyskočil V. Vitamin D. Klinická farmakologie a farmacie 2011; 25: 72–75.

3. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 2009; 339: b3692.

4. Dietary suplement fact sheet: Vitamin D. Office of Dietary Supplements. National Institute of Health 2011; 2: 1–15.

5. Kiebzak GM, Moore NL, Margolis S et al. Vitamin D status of patients admitted to a hospital rehabilitation unit: relationship to function and progress. Am J Phys Med Rehabil 2007; 86: 435–445.

6. Matějovská Kubešová H. Problematika vitaminu D u seniorů. Gerontologický kongres Hradec Králové, prosinec 2010, sborník abstrakt.

7. Vyskočil V. Současné možnosti léčby osteoporózy. Vnitř Lék 2010; 56: 749–758.

8. Cranney A, Horsley T, O’Donnell S et al. Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess 2007; 158: 1–235.

9. Cavalier E, Delanaye P, Souberbielle JC et al. Vitamin D and type 2 diabetes mellitus: Where do we stand? Diabetes Metab 2011; 37: 265–272.

10. Matějovská Kubešová H, Holík J, Weber Pet al. Výživa jako nástroj pro podporu zdraví a udržení kondice ve vyšším věku. Protis s. r. o. 2008.

11. Ovesen L, Brot C, Jakobsen J. Food contents and biological activity of 25-hydroxyvitamin D: a vitamin D metabolite to be reckoned with? Ann Nutr Metab 2003; 47: 107–113.

12. Reid IR, Bolland MJ, Avenell A et al. Cardiovascular effects of calcium supplementation. Osteoporos Int 2011; 22: 1649–1658.

13. Morelli S, Buitrago C, Vasquez G et al. Involvement of tyrosine kinase activity in 1α,25(OH)2-vitamin D3 signal transduction in skeletal muscle cells. J Biol Chem 2000; 275: 3021–3028.

14. Scott D, Blizzard L, Fell J et al. A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults. Clin Endocrinol 2010; 73: 581–587.

15. Bauer JM, Kaiser MJ, Sieber CC. Sarcopenia in nursing home residents. J Am Med Dir Assoc 2008; 9: 545–551.

16. Verchueren SM, Bogaerts A, Delecluse C et al. The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: a 6-month randomized, controlled trial. J Bone Miner Res 2011; 26: 42–49.

17. Morley JE, Argiles JM, Evans WJ et al. Society for Sarcopenia, Cachexia, and Wasting Disease. Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc 2010; 11: 391–396.

18. Oudshoom C, Mattace Raso FU, van der Velde N et al. Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer’s disease. Dement Geriatr Cogn Disord 2008; 25: 539–543.

19. Evatt ML, Delong MR, Khazai N et al. Prevalence of vitamin D insufficiency in patiens with Parkinson disease and Alzheimer disease. Arch Neurol 2008; 65: 1348–1352.

20. Gezen-Ak D, Dursun E, Ertan T et al. Association between vitamin D receptor gene polymorphism and Alzheimer’s disease. Tohoku J Exp Med 2007; 212: 275–282.

21. Fujita T. Alzheimer disease and calcium. Clin Calcium 2004; 14: 103–105.

22. Stumpf WE, Privette TH. Light, vitamin D and psychiatry. Role of 1,25 dihydroxyvitamin D3 (soltriol) in ethiology and therapy of seasonal affective disorders and other mental processes. Psychopharmacology 1989; 97: 285–294.

23. Landsdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology 1998; 135: 319–323.

24. Kenny AM, Biskup B, Robbins B et al. Effect of vitamin D supplementation on strength, physical function and health perception in older, community-dwelling men. J Am Geriatr Soc 2003; 51: 1762–1767.

25. Lambert GW, Reid C, Kaye DM et al. Effect of sunlight and season on serotonin turnover in the brain. Lancet 2002; 360: 1840–1842.

26. Capiati DA, Rossi AM, Piccoto D et al. Inhibition of serum-stimulated mitogen activated protein kinase by 1α,25(OH)2-vitamin D3 in MCF-7 breast cancer cells. J Cell Biochem 2004; 93: 384–397.

27. Field S, Newton-Bishop JA. Melanoma and vitamin D. Mol Oncol 2011; 5: 197–214.

28. Peppone L, Rickles A, Huston A et al. The Association between Prognostic Demographic and Tumor Characteristics of Breast Carcinomas with Serum 25-OH Vitamin D Levels. Cancer Epidemiol Biomarkers Prev 2011; 20: 717.

29. Berwick M. Can UV Exposure Reduce the Mortality? Cancer Epidemiol Biomarkers Prev 2011; 20: 582–584.

30. Adams SV, Newcomb PA, Burnett-Hartmann AN et al. Circulating 25-Hydroxyvitamin-D and Risk of Colorectal Adenomas and Hyperplastic Polyps. Nutr Cancer 2011; 63: 319–326.

31. Lee JE, Li H, Chan AT et al. Circulating levels of vitamin D and colon and rectal cancer: the Physicians’ Health Study and a meta-analysis of prospective studies. Cancer Prev Res (Phila) 2011; 4: 735–743.

32. Hayes CE, Nashold FE, Spach KM et al. The immunolgical fuctions of the vitamin D endocrine system. Cell Mol Biol 2003; 49: 277–300.

33. Hansdottir S, Monick MM. Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm 2011; 86: 217–237.

34. Hewison M. Vitamin D and innate and adaptive immunity. Vitam Horm 2011; 86: 23–62.

35. Herr C, Greulich T, Koczulla RA et al. The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer. Respir Res 2011; 12: 31.

36. Cutolo M, Plebani M, Schoenfeld Y et al. Vitamin D endocrine system and the immune response in rheumatic diseases. Vitam Horm 2011; 86: 327–351.

37. Bikkle DD. Vitamin D regulation of immune function. Vitam Horm 2011; 86: 1–21.

38. Kvapil M. Diabetologie 2011. Praha: Triton 2011.

39. Devaraj S, Yun JM, Duncan-Staley CR et al. Low vitamin D levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications. Am J Clin Pathol 2011; 135: 429–433.

40. Bizzari C, Pittoco D, Napoli N et al. IMDIAB Group. No protective effect of calcitriol on β-cell function in recent-onset type 1 diabetes: the IMDIAB XIII trial. Diabetes Care 2010; 33: 1962–1963.

41. Aljabri KS, Bogari SA, Khan MJ. Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency. Ann Saudi Med 2010; 30: 454–458.

42. Hyppönen E. Vitamin D and increasing incidence of type I diabetes mellitus – evidence for an association? Diabetes Obes Metab 2010; 12: 737–743.

43. Yiu YF, Chan YH, Yiu KH et al. Vitamin D Deficiency Is Associated with Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients with Type 2 Diabetes. J Clin Endocrinol Metab 2011; 2: E830–E835.

44. Binkley N, Krueger D, Cowgill CS et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J. Clin Endocrinol Metab 2004; 89: 3152–3157.