Indicators of inflammation in patients with coronary atherosclerosis – role of usCRP in diagnosis and disease progression prediction

Česká verzia

Authors: M. Samoš ¹; R. Pullmann ²; S. Funiak ¹; M. Stančík ¹; M. Mokáň ¹
Authors place of work: I. interná klinika Jesseniovej lekárskej fakulty UK a UN Martin, Slovenská republika, prednosta prof. MUDr. Marián Mokáň, DrSc., FRCP Edin. ¹; Ústav klinickej biochémie Jesseniovej lekárskej fakulty UK a UN Martin, Slovenská republika, prednosta prof. MUDr. Dušan Dobrota, CSc. ²
Published in the journal: Vnitř Lék 2013; 59(12): 1057-1064
Category: Review

Summary

Atherosclerosis is being nowadays defined as chronic subclinical inflammatory disease. Recently published clinical and laboratory studies have shown that subclinical inflammation represents main role in initiation of creation, in progress and destabilization of atherosclerotic plaque. Screening including traditional cardiovascular risk factors fails in identification in more than 50% of individuals with later development of acute coronary syndrome. According to above mentioned reason indicators are being searched for, which would be usable to monitor the activity of atherosclerotic process. According to role of subclinical inflammatory process in pathogenesis of atherosclerosis, the determination of C-reactive protein using ultrasensitive method is being showed as perspective marker. Ultrasensitive C-reactive protein represents a strong, independent predictor of future cardiovascular events in apparently healthy individuals and has also prognostic utility in patients with acute coronary syndromes. Predictive capacity of C-reactive protein determination is independent of traditional risk factors and offers prognostic advantage as opposed to determination of lipids alone. The paper provides a review of currently available knowledge of possibilities for utilization of C-reactive protein laboratory assessment, as the main representative of acute phase proteins, in monitoring of creation and severity of coronary atherosclerosis, in possibilities of the disease prognosis determination and prediction of its acute complications, and also in prediction of prognosis in patient with already existing acute complication.

Key words:
ultrasensitive C-reactive protein – coronary atherosclerosis – myocardial infarction

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