Diastolic dysfunction in the elderly subjects. Disease or a physiological manifestation of ageing?

Česká verzia

Authors: J. Meluzín ^1,2; H. Podroužková ^1,2; Z. Gregorová ^1,2; R. Panovský ^1,2
Authors place of work: I. interní kardio‑angiologická klinika Lékařské fakulty MU a FN u sv. Anny Brno, přednostka prof. MU Dr. Lenka Špinarová, Ph. D., FESC ¹; Oddělení kardiovaskulárních chorob ICRC Brno, vedoucí programu MU Dr. Marek Orban ²
Published in the journal: Vnitř Lék 2013; 59(5): 392-396
Category: Review

Summary

Aim:
The purpose of this summary paper is to discuss the current knowledge of the impact of age on diastolic function of the left ventricle.

Data from the literature:
Reports published till this time have convincingly demonstrated a significant relationship of age to diastolic function of the left ventricle. Ageing is a physiological process accompanied by structural changes in both myocardium and arterial bed resulting in worsening of parameters characterizing the left ventricular diastolic function. This „physiological” diastolic dysfunction in the elderly subjects can be explained by the deterioration of passive left ventricular filling properties and by worsening of left ventricular relaxation. The detailed analysis of published reports shows problems in distiguishing this „physiological” diastolic dysfunction resulting from physiological tissue ageing from „pathological” diastolic dysfunction reflecting a disease of cardiovascular system.

Conclusion:
To interprete correctly values of parameters quantifying diastolic function of the left ventricle, one should take into account the age of subjects under the examination. Further studies are necessary to distinguish exactly „physiological” deterioration of diastolic function associated with ageing from really „pathological” diastolic dysfunction in the elderly subjects.

Key words:
ageing – echocardiography – diastolic dysfunction – diastolic heart failure

Zdroje

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