Systemic glucocorticoids treatment: practical view

Česká verzia

Authors: Michal Kršek
Authors place of work: III. interní klinika – klinika endokrinologie a metabolizmu 1. LF UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
Published in the journal: Vnitř Lék 2015; 61(10): 905-913
Category: Reviews

Summary

Glucocorticoids are derivatives of natural human glucocorticoid cortisol. There are used for treatment of a number of diseases and disorders for more than 65 years mainly because of their immunosuppressive properties. However, their use is accompanied by various side effects that have to be considered when treating patients. The article summarizes biological effects of glucocorticoids, main indications for their use, their side effects and precautions necessary to bear in mind during treatment.

Key words:
glucocorticoids – side effects – treatment

Zdroje

1. Hench PS, Kendall EC et al. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc Staff Meet Mayo Clin 1949; 24(8): 181–197.

2. Exton JH. Mechanisms of hormonal regulation of hepatic glucose metabolism. Diabetes Metab Rev 1987; 3(1): 163–183.

3. Fain JN. Inhibition of glucose transport in fat cells and activation of lipolysis by glucocorticoids. In: Baxter JD, Rousseau GG (eds). Glucocorticoid Hormone Action. Springer: Berlin 1979: 547–560. ISBN 978–3540089735.

4. Carter-Su C, Okamoto K. Effect of glucocorticoids on hexose transport in rat adipocytes: Evidence for decreased transporters in the plasma membrane. J Biol Chem 1985; 260(20): 11091–11098.

5. Clore JN, Estep H, Ross-Clunis H et al. Adrenocorticotropin and cortisol-induced changes in urinary sodium and potassium excretion in man: Effects of spironolactone and RU 486. J Clin Endocrinol Metab 1988; 67(4): 824–831.

6. Freiberg JM, Kinsella J, Sacktor B. Glucocorticoids increase the Na+-H+ exchange and decrease the Na+ gradient-dependent phosphate-uptake systems in renal brush border membrane vesicles. Proc Natl Acad Sci USA 1982; 79(16): 4932–4936.

7. Cronstein BN, Kimmel SC, Levin RJ et al. A mechanism for the antiinflammatory effect of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intracellular adhesion molecule 1. Proc Natl Acad Sci USA 1992; 89(21): 9991–9995.

8. Collins S, Caron MG, Lefkowitz RJ. Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J Biol Chem 1988; 263(19): 9067–9070.

9. Meikle AW, Tyler FH. Potency and duration of action of glucocorticoids. Effects of hydrocortisone, prednisone and dexamethasone on human pituitary-adrenal function. Am J Med 1977; 63(2): 200–207.

10. Harter JG. Corticosteroids: their physiologic use in allergic disease. NY State J Med 1966; 66: 827–840.

11. Axelrod L. Glucocorticoid therapy. Medicine (Baltimore) 1976; 55(1): 39–65.

12. Axelrod L. Adrenal corticosteroids. In: Miler RR, Greenblatt DJ (eds). Handbook of drug Therapy. Elsevier North-Holland: New York: 1979.

13. Axelrod L. Glucocorticoids. In: Kelley WN, Harris ED jr, Ruddy S (eds). Textbook of Rheumatology. 4th ed. WB Saunders: Philadelphia 1993. ISBN 9780721631561.

14. van Raalte DH, Ouwens DM, Diamant M. Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options? Eur J Clin Invest 2009; 39(2): 81–93.

15. Mazziotti G, Gazzaruso C, Giustina A. Diabetes in Cushing syndrome: basic and clinical aspects. Trends Endocrinol Metab 2011; 22(12): 499–506.

16. Munir A, Newell-Price J. Management of diabetes mellitus in Cushing’s syndrome. Neuroendocrinology 2010; 92(Suppl 1): S82-S85.

17. Mancini T, Kola B, Mantero F et al. High cardiovascular risk in patients with Cushing’s syndrome according to 1999 WHO/ISH guidelines. Clin Endocrinol 2004; 61(6): 768–777.

18. Albaum JM, Youn S, Levesque LE et al. Osteoporosis management among chronic glucocorticoid users: a systematic review. J Popul Ther Clin Pharmacol 2014; 21(3): e486-e504. Dostupné z WWW: <http://www.jptcp.com/pubmed.php?articleId=488>.

19. Marek J. Terapie kortikoidy. In: Marek J (ed) et al. Farmakoterapie vnitřních nemocí. Praha: Grada 2005: 405–412. ISBN 80–247–0839–6.