The TECOS, EXAMINE and SAVOR studies – how do they differ and what are their outcomes?

Česká verzia

Authors: Jindřich Špinar ^1,3; Lenka Špinarová ²; Jiří Vítovec ²
Authors place of work: Interní kardiologická klinika LF MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jindřich Špinar, CSc., FESC ¹; I. interní kardio-angiologická klinika LF MU a FN u sv. Anny v Brně, přednostka prof. MUDr. Lenka Špinarová, CSc., FESC ²; Mezinárodní centrum klinického výzkumu – FN u sv. Anny v Brně, ředitel Gorazd B. Stonkin, M. D., MSc., PhD. ³
Published in the journal: Vnitř Lék 2015; 61(11): 976-983
Category: Reviews

Summary

The treatment of diabetes mellitus type 2 is effective, but still is not optimal. DPP4 inhibitors (gliptins) are a new group of peroral antidiabetic drugs. The third clinical mortality study with gliptins in patients with diabetes mellitus type 2 was finished in 2015. The studies are known under acronym TECOS, SAVOR and EXAMINE and the tested drugs are sitagliptin, saxagliptin and alogliptin. The studies included about 37 000 patients. The studies confirmed the cardiovascular safety of the DPP4 inhibitors, but the question about increased heart failure remains open. The effectiveness of lowering glycaemia (glycated haemoglobin) was confirmed and also the pancreatic safety is confirmed.

Key word:
effectiveness – gliptins – safety

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