Insulin analogues of patients with diabetes and renal impairment

Česká verzia

Authors: Alena Adamíková
Authors place of work: Diabetologické centrum Interní kliniky Krajské nemocnice T. Bati, a. s., Zlín, přednosta prim. MUDr. Jiří Latta
Published in the journal: Vnitř Lék 2015; 61(2): 147-150
Category: Review

Summary

The main cause of renal failure is diabetic nephropathy which affects 20–40 % of diabetic patients. Diabetics with altered renal function have restricted therapeutic options due to the risk of accumulation of oral antidiabetic drugs and of their metabolites at a reduced glomerular filtration rate. Good metabolic control is very important during the early phases of nephropathy for reducing the risk of progression and in the stage of renal failure reduces the risk of progression of atherosclerosis and improves life prognosis. Metabolism of insulin is changed during renal failure, clearance of insulin is prolonged, the risk of hypoglycemia increases. Short-acting insulin analogues have faster absorption and long-acting analogues have a lower risk of hypoglycemia. Thus they can positively affect glycemic control of patients with diabetes and impaired renal function.

Key words:
diabetic nephropathy – insulin analogues – renal impairment

Zdroje

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